Cloned genes encoding reverse transcriptase lacking RNase H activity

  • US 6,589,768 B1
  • Filed: 12/24/1998
  • Issued: 07/08/2003
  • Est. Priority Date: 01/13/1988
  • Status: Expired due to Fees
First Claim
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1. A retroviral reverse transcriptase having DNA polymerase activity, wherein said reverse transcriptase allows an mRNA template to remain intact during cDNA synthesis by said reverse transcriptase and wherein said reverse transcriptase is modified within the RNase H domain.

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