Disposable unit-dose jet-injection syringe for pre-filled and/or transfilled liquid injectable medical drug or vaccine products and method thereof

• US 6,610,042 B2
• Filed: 02/14/2001
• Issued: 08/26/2003
• Est. Priority Date: 12/05/1997
• Status: Expired due to Fees

• Current Assignee: Felton International Incorporated, Pulse Needlefree Systems, Inc.
• Original Assignee: Felton Medical, Inc.
• Inventors: Leon, Nathaniel, Gerwig, Phillip L.
• Primary Examiner(s): Casler, Brian L.
• Assistant Examiner(s): RODRIGUEZ, CRIS LOIREN
• Application Number:
  US09/783,444
• Publication Number:
  US 20020065483A1
• Time in Patent Office: 923 Days
• Field of Search: 604/68-72, 604/232-235, 604/500, 604/124, 604/125, 604/131, 604/187, 604/134-136, 604/181, 604/183, 604/200, 604/218, 604/227, 604/236, 604/244, 604/403, 604/408, 604/231, 604/411-415, 222/631, 222/386, 222/324-327, 222/372
• US Class Current: 604/500
• CPC Class Codes: A61M 5/19 having more than one chamber , e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly surgical glue applicators A61B17/00491
• CPC Class Codes: A61M 5/204 connected to external reservoirs for multiple refilling
• CPC Class Codes: A61M 5/2448 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules

Abstract

A disposable unit-dose jet injection syringe having a cylindrically shaped syringe body. The syringe body has a rear open end and a forward closed end. The rear open end has an enlarged diameter forming a flange that retains the syringe to the driving system during the injection cycle. The closed end has an small area coined by a stamping process. A jet orifice is punched through the small area of the closed end. A cavity formed in syringe body is configured to hold a unit dose of liquid, drug, or biological. A piston is slidably engaged within the body to inject the unit dose. A driving system activates the piston to inject the unit dose out of the jet orifice. A method of manufacturing a jet injection syringe is also provided. A method of injecting a medicine is also provided.

Claims

1. A method of injecting a unit dose of medicine, comprising:

a. connecting a bulk container of the unit dose to a driving system;

b. connecting a syringe to the driving system, the syringe having a rear open end, a forward closed end and a cavity positioned in between;

c. drawing the unit dose from the bulk container through a channel in a piston in the cavity;

d. activating the piston through the cavity toward the forward closed end of the syringe; and

e. injecting the unit dose by the piston through a jet orifice positioned on the forward closed end.

2. The method according to claim 1, wherein the unit dose comprises a liquid medicine.

3. The method according to claim 1, wherein the unit dose comprises a lyophilized medicine.

4. The method of claim 1, wherein drawing the unit dose from the bulk container through the channel in the piston in the cavity comprises drawing the unit dose through a check valve in the channel in the piston.

5. The method of claim 1, wherein connecting the bulk container of the unit dose to the driving system comprises:

(i) connecting the bulk container of the unit dose to a filler adapter; and

(ii) connecting the filler adapter to the driving system.

6. The method of claim 5, wherein drawing the unit dose from the bulk container through the channel in the piston comprises a dry break coupling of the filler adapter withdrawing the piston from the forward closed end to the rear open end of the syringe.

7. A method for transfilling at least one syringe having a rear open end, a forward closed end and a cavity positioned in between with a unit dose of medicine comprising:

(a) connecting a bulk container of the unit dose to a filler adapter;

(b) connecting the filler adapter to a driving system;

(c) attaching the rear open end of the at least one syringe to the driving system;

(d) activating the driving system; and

(e) drawing the unit dose from the bulk container through a channel in a piston in a cavity of the at least one syringe.

8. The method of claim 7, wherein drawing the unit dose from the bulk container through the channel in the piston comprises drawing the unit dose from the bulk container through the filler adapter to the channel in the piston.

9. The method of claim 7, wherein drawing the unit dose from the bulk container through the channel in the piston comprises drawing the unit dose from the bulk container through a check valve in the channel of the piston.

10. The method of claim 7, wherein drawing the unit dose from the bulk container through the channel in the piston comprises a dry break coupling of the filler adapter withdrawing the piston from the forward closed end to the rear open end of the at least one syringe.