Cloned genes encoding reverse transcriptase lacking RNase H activity

  • US 6,610,522 B1
  • Filed: 12/24/1998
  • Issued: 08/26/2003
  • Est. Priority Date: 01/13/1988
  • Status: Expired due to Fees
First Claim
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1. A composition, comprising(a) an mRNA template;

  • and (b) a retroviral reverse transcriptase having DNA polymerase activity, wherein said reverse transcriptase allows the mRNA template to remain intact during a one minute cDNA synthesis reaction by said reverse transcriptase as determined by gel electrophoresis and wherein said reverse transcriptase is modified within the RNase H domain.

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