Stent having cover with drug delivery capability

• US 6,613,084 B2
• Filed: 11/28/2001
• Issued: 09/02/2003
• Est. Priority Date: 03/13/2000
• Status: Expired due to Fees

• Current Assignee: Jun Yang
• Original Assignee: Jun Yang
• Inventors: Yang, Jun
• Primary Examiner(s): Willse, David H.
• Assistant Examiner(s): GHERBI, SUZETTE JAIME J
• Application Number:
  US09/997,072
• Publication Number:
  US 20020062147A1
• Time in Patent Office: 643 Days
• Field of Search: 623/1-2-, 623/1.13, 600/3
• US Class Current: 623/1.42
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2002/072 Encapsulated stents, e.g. wire or whole stent embedded in lining
• CPC Class Codes: A61F 2002/075 the stent being loosely attached to the graft material, e.g. by stitching
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61L 2300/00 Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/12 Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
• CPC Class Codes: A61L 31/145 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: C08L 89/00 Compositions of proteins; Compositions of derivatives thereof foodstuff preparations A23J3/00

Abstract

A prosthesis has a stent, and a cover that covers a portion of the stent. The cover has at least two layers of materials that can define at least one chamber therebetween, with a drug loaded into the at least one chamber by a dug dispersing element. The cover can be provided inside the luminal walls of the stent, or the stent can be retained in the at least one chamber. The cover can also be deployed to treat vulnerable plaque.

Claims

1. A prosthesis, comprising:

a stent having an outer periphery;

a cover provided about the outer periphery of the stent, the cover comprising at least two layers of materials, with at least one layer of material being permeable to drugs; and

a drug dispersing element coupled to the cover.

2. The prosthesis of claim 1, wherein the at least two layers of materials defines at least one chamber therebetween.

3. The prosthesis of claim 2, wherein the drug dispersing element is a microtubing that is positioned inside the at least one chamber.

4. The prosthesis of claim 1, wherein at least one of the layers has at least one perforation.

5. The prosthesis of claim 1, wherein one of the layers is impermeable to drugs.

6. The prosthesis of claim 1, wherein the drug dispersing element is a distributor ring positioned around the stent, the distributor ring having a plurality of venting openings.

7. The prosthesis of claim 1, wherein the drug dispersing element is a microtubing that extends along the cover, the microtubing having a plurality of venting openings.

8. The prosthesis of claim 1, wherein the drug dispersing element is removable from the cover.

9. A prosthesis, comprising:

a stent having an inner periphery that defines a lumen;

a cover provided about the inner periphery of the stent, the cover comprising at least two layers of materials that are positioned inside the lumen of the stent, with at least one layer of material being permeable to drugs; and

a drug dispensing element courled to the cover.

10. The prosthesis of claim 9, wherein the at least two layers of materials defines at least one chamber therebetween.

11. The prosthesis of claim 9, wherein one of the layers has at least one perforation.

12. A prosthesis, comprising:

a stent having an inner periphery that defines a lumen; and

a cover provided about the inner periphery of the stent, the cover comprising at least two layers of materials that are positioned inside the lumen of the stent, with at least one layer of material being permeable to drugs.

13. A prosthesis, comprising:

a stent;

a cover that extends across a portion of the stent, the cover comprising at least two layers of materials that are completely sealed to define at least one chamber therebetween; and

a radioactive material provided inside the at least one chamber.

14. The prosthesis of claim 13, wherein the stent has an inner periphery that defines a lumen, and wherein the cover is provided inside the lumen adjacent the inner periphery of the stent.

15. The prosthesis of claim 13, wherein the at least two layers of material are selected from the group consisting of:

polyurethane, silicone, silicone-polyurethane copolymer, and fluoro-containing polymer.