System and method for treating kidney diseases in diabetic and non-diabetic patients

  • US 6,613,342 B2
  • Filed: 06/15/2001
  • Issued: 09/02/2003
  • Est. Priority Date: 06/16/2000
  • Status: Expired due to Term
First Claim
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1. A method for treating kidney disease in diabetic and non-diabetic patients through an intravenous site administering a pulse of insulin to a patient comprising the steps of:

  • a) determining a steady baseline respiratory quotient of the patient and obtaining a subsequent respiratory quotient every 30 minutes, the steady baseline respiratory quotient being two identical consecutive respiratory quotients less than 0.90 measured five minutes apart, b) having the patient consume a liquid or food containing 60 to 100 grams of glucose, c) administering the pulse of insulin at a regular interval of time until the subsequent respiratory quotient shows an improvement over the steady baseline respiratory quotient, the improvement over the steady baseline respiratory quotient being a respiratory quotient of 0.90 or greater, the subsequent respiratory quotient improvement over the steady baseline respiratory quotient being a measurement of sufficient insulin pulses to achieve a more normal metabolic function of a diseased kidney, the more normal metabolic function of a diseased kidney being a stabilization or decrease in 24-hour urinary protein excretion or a stabilization or increase in creatinine clearance, d) providing the patient a rest period, and e) repeating the steps a-d at least three times.

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