Apparatus for adjunct (add-on) therapy of Dementia and Alzheimer's disease utilizing an implantable lead and an external stimulator
First Claim
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1. An Alzheimer'"'"'s disease and dementia therapy apparatus for providing pulsed electrical stimulation to a cranial nerve, comprising:
- a) an implantable lead-receiver comprising circuitry, a secondary coil, and least one electrode adapted to be in contact with a cranial nerve;
b) an external stimulator comprising a power source, circuitry to emit electrical signals, more than two predetermined programs to control said electrical signals, and a primary coil;
c) said primary coil of external stimulator and said secondary coil of implantable lead-receiver being capable of forming an electrical connection by inductive coupling, whereby said external stimulator controls said stimulation to said cranial nerve.
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Abstract
An apparatus and method for adjunct (add-on) therapy for dementia and Alzheimer'"'"'s disease comprises an implanted lead-receiver, and an external stimulator. The implanted lead receiver comprises a secondary coil and at least one electrode in contact with a cranial nerve. The external stimulator comprises circuitry, at least two pre-determined programs, power source and a primary coil. The stimulator and the lead-receiver are inductively coupled. The external stimulator emits pulsed electrical signals according to predetermined programs for afferant vagal nerve stimulation.
160 Citations
28 Claims
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1. An Alzheimer'"'"'s disease and dementia therapy apparatus for providing pulsed electrical stimulation to a cranial nerve, comprising:
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a) an implantable lead-receiver comprising circuitry, a secondary coil, and least one electrode adapted to be in contact with a cranial nerve;
b) an external stimulator comprising a power source, circuitry to emit electrical signals, more than two predetermined programs to control said electrical signals, and a primary coil;
c) said primary coil of external stimulator and said secondary coil of implantable lead-receiver being capable of forming an electrical connection by inductive coupling, whereby said external stimulator controls said stimulation to said cranial nerve. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A dementia and Alzheimer'"'"'s disease therapy apparatus for neuromodulating a cranial nerve, comprising:
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a) an implantable lead-receiver comprising circuitry, a secondary coil, and least one electrode adapted to be in contact with a cranial nerve;
b) an external stimulator comprising a power supply, circuitry to emit electrical signals, more than two predetermined programs to control said electrical signals, and a primary coil;
c) means for optimizing coupling between said primary coil and said secondary coil;
d) said primary coil of said external stimulator and said secondary coil of said implantable lead-receiver being capable of forming an electrical connection by inductive coupling, whereby said external stimulator neuromodulates said cranial nerve. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. An apparatus to provide therapy for Alzheimer'"'"'s disease and dementia by providing pulsed electric stimulation to a vagus nerve, comprising:
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a) an implantable lead-receiver comprising, circuitry, a secondary coil, and at least one electrode adapted to be in contact with a vagus nerve;
b) an external stimulator comprising a power supply, circuitry to emit electrical signals, more than two predetermined programs to control said electrical signals, and a primary coil;
c) said primary coil of said external stimulator and said secondary coil of said implantable lead-receiver being capable of forming an electrical connection by inductive coupling, whereby said external stimulator is capable of controlling said stimulation to said vagus nerve. - View Dependent Claims (28)
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Specification