Microsphere containing sensor

• US 6,627,057 B1
• Filed: 12/23/1999
• Issued: 09/30/2003
• Est. Priority Date: 12/23/1999
• Status: Expired due to Fees

• Current Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Original Assignee: Roche Diagnostics Corporation (Roche Holding AG)
• Inventors: Bhullar, Raghbir Singh, Hill, Brian
• Primary Examiner(s): Tung, T.
• Assistant Examiner(s): NOGUEROLA, ALEXANDER STEPHAN
• Application Number:
  US09/471,571
• Time in Patent Office: 1,377 Days
• Field of Search: 204/403, 204/416, 204/409, 204/415, 204/419, 204/403.01, 204/403.1
• US Class Current: 204/403.01
• CPC Class Codes: G01N 27/3272 Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels optical biosensors G01N33/52

Abstract

A sensor strip comprises an electrode substrate, an electrode set, on the electrode substrate, and microspheres. The sensor strip allows for a smaller sample volume and maintain a more uniform flow profile through the sample channel.

Claims

1. A sensor strip for determining the concentration of an analyte in a biological sample, comprising:

(a) an electrode substrate,

(b) an electrode set, on said electrode substrate,

(c) microspheres, said microspheres comprising glass, silica or latex, and

(d) a cover on said electrode set, wherein said cover, said electrode set, and said electrode substrate together define a channel, and said microspheres are in said channel.

2. The sensor strip of claim 1, wherein said microspheres are on said electrode set.

3. The sensor strip of claim 2, further comprising:

(e) reagent on said microspheres.

4. The sensor strip of claim 3, wherein said microspheres have an average diameter of 1 to 300 μ

m.

5. The sensor strip of claim 2, wherein said microspheres are homogeneously hydrophilic.

6. The sensor strip of claim 1, wherein said microspheres are homogeneously hydrophilic.

7. Packaged sensor strips, comprising:

a plurality of the sensor strips of claim 1,

a vial, containing said plurality of said sensor strips, and

a stopper, sealing said vial.

8. A sensor strip for determining the concentration of an analyte in a biological sample, comprising:

(a) an electrode substrate;

(b) an electrode set, on said electrode substrate;

(c) microspheres;

(d) a cover on said electrode set, wherein said cover, said electrode set, and said electrode substrate together define a channel, and said microspheres are in said channel, and

(e) reagent on said microspheres.

9. The sensor strip of claim 8, further comprising:

(f) a dielectric, on said electrode substrate,

wherein said dielectric, said cover, said electrode set, and said electrode substrate together define said channel.

10. The sensor strip of claim 8, wherein said microspheres have an average diameter of 1 to 300 μ

m.

11. A sensor strip, comprising:

(a) an electrode substrate,

(b) an electrode set, on said electrode substrate,

(c) microspheres,

(d) a cover, on said electrode set, and

(f) a dielectric, on said electrode substrate,

wherein said dielectric, said cover, said electrode set, and said electrode substrate together define a channel, and

said microspheres are in said channel.

12. Packaged sensor strips, comprising:

a plurality of the sensor strips of claim 11,

a vial, containing said plurality of said sensor strips, and

a stopper, sealing said vial.

13. A sensor strip, comprising:

(a) an electrode substrate,

(b) an electrode set, on said electrode substrate,

(c) microspheres, wherein said microspheres comprise glass, silica or latex, and

(d) a cover, on said electrode set,

wherein said cover, said electrode set, and said electrode substrate together define a channel, and

said microspheres are in said channel.

14. A sensor strip, comprising:

(a) an electrode substrate,

(b) an electrode set, on said electrode substrate,

(c) microspheres,

(d) a cover on said electrode set, wherein said cover, said electrode set, and said electrode substrate together define a channel, and said microspheres are in said channel, and

(e) reagent on said microspheres.