Molecular and atomic scale evaluation of biopolymers

  • US 6,627,067 B1
  • Filed: 06/22/2000
  • Issued: 09/30/2003
  • Est. Priority Date: 06/22/1999
  • Status: Active Grant
First Claim
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1. An apparatus for use in evaluating a linear polymer molecule, comprising:

  • a vessel for holding a liquid containing a candidate polymer molecule;

    a solid-state membrane containing an aperture therein, said aperture comprising a constraining dimension, wherein the aperture includes an entry port and an exit port defining a channel there between, and wherein the membrane is positioned to be contactable with a liquid in the vessel;

    means for causing a candidate polymer molecule to linearly traverse the aperture; and

    a detector for detecting sensing time-dependent or monomer-dependent interactions of a candidate molecule with the aperture detector, said detector located in the aperture or on a face of the solid-state membrane.

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