Polysiloxane-containing polyurethane elastomeric compositions
First Claim
1. A polyurethane elastomeric composition comprising a hard segment and a soft segment, wherein the soft segment is formed from(a) a combination of at least one polyether macrodiol and at least one polycarbonate macrodiol, wherein the polyether macrodiol is a compound of the formula:
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Abstract
The present invention relates to a material having improved mechanical properties, clarity, processability and/or degradation resistance comprising a polyurethane elastomeric composition which includes a soft segment derived from at least one polysiloxane macrodiol and at least one polyether and/or polycarbonate macrodiol. This material can function as a degradation-resistant material or biomaterial and is particularly useful in the manufacture of medical devices, articles or implants which contact living tissue or bodily fluids. The present invention also provides a polyurethane elastomeric composition which includes a soft segment derived from at least one polysiloxane and at least one polyether and/or polycarbonate macrodiol and processes for its preparation.
109 Citations
43 Claims
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1. A polyurethane elastomeric composition comprising a hard segment and a soft segment, wherein the soft segment is formed from
(a) a combination of at least one polyether macrodiol and at least one polycarbonate macrodiol, wherein the polyether macrodiol is a compound of the formula:
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16. A device or article comprising an amount of a polyurethane elastomeric composition effective to render the device biocompatible, the polyurethane elastomeric composition comprising a hard segment and a soft segment, wherein the soft segment is formed from (a) a combination of at least one polyether macrodiol and at least one polycarbonate macrodiol;
- and (b) at least one polysiloxane macrodiol of formula (I);
wherein R1, R2, R3, R4, R5, and R6 are each independently an optionally substituted straight chain, branched or cyclic, saturated or unsaturated hydrocarbon radical; and
n is an integer from 1 to 100. - View Dependent Claims (17, 18, 19, 32)
- and (b) at least one polysiloxane macrodiol of formula (I);
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20. A device or article comprising a polyurethane elastomeric composition comprising a hard segment and a soft segment, wherein the soft segment is formed from
(a) a combination of at least one polyether macrodiol and at least one polycarbonate macrodiol, wherein the polyether macrodiol is a compound of the formula:
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21. A process for preparing a polyurethane elastomeric composition comprising:
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a) mixing a polysiloxane macrodiol, a polyether macrodiol, a polycarbonate macrodiol, and a chain extender; and
b) reacting the mixture with a diisocyanate to yield a polyurethane elastomeric composition comprising a hard segment which is the product of a diisocyanate and a chain extender; and
a soft segment which is the product of;
i) at least one polysiloxane macrodiol; and
ii) a combination of at least one polyether macrodiol and at least one polycarbonate macrodiol, wherein the polyether macrodiol is a compound of the formula;
- View Dependent Claims (22, 23, 24, 25)
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26. A process for preparing a polyurethane elastomeric composition comprising:
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a) reacting a diisocyanate with a polysiloxane macrodiol, a polyether macrodiol, and a polycarbonate macrodiol, to form a prepolymer having terminally reactive diisocyanate groups; and
b) reacting the prepolymer with a chain extender to yield a polyurethane elastomeric composition comprising a soft segment which is the product of (a) at least one polysiloxane macrodiol; and
(b) a combination of at least one polyether macrodiol and at least one polycarbonate macrodiol, wherein the polyether macrodiol is a compound of the formula;
- View Dependent Claims (27, 28, 29, 30, 31)
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33. A process for preparing a polyurethane elastomeric composition comprising a hard segment and a soft segment comprising:
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a) forming a prepolymer having terminally reactive diisocyanate groups, and i) internal polysiloxane groups; and
ii) internal polyether and polycarbonate groups; and
b) reacting the prepolymer with a chain extender to yield a polyurethane elastomeric composition, wherein the polyether groups in the prepolymer, are provided by reaction of a polyether macrodiol of the formula;
- View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
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Specification