Methods for remote characterization of an odor

• US 6,631,333 B1
• Filed: 06/15/2000
• Issued: 10/07/2003
• Est. Priority Date: 05/10/1999
• Status: Expired due to Term

• Current Assignee: California Institute of Technology
• Original Assignee: California Institute of Technology
• Inventors: Severin, Erik, Lewis, Nathan S.
• Primary Examiner(s): Barlow, John
• Assistant Examiner(s): Washburn, Douglas N
• Application Number:
  US09/596,758
• Time in Patent Office: 1,209 Days
• Field of Search: 73/23, 73/232, 73/233, 73/233.4, 73/310.5, 73/250.1, 205/787, 364/496, 364/497, 422/82.2, 422/95, 422/98, 436/147, 436/151, 436/43, 702/22, 702/23, 702/24, 702/30
• US Class Current: 702/24
• CPC Class Codes: G01N 33/0031 comprising two or more sensors, e.g. a sensor array electrochemical electrode arrays G01N27/27
• CPC Class Codes: G01N 33/0075 for multiple spatially distributed sensors, e.g. for environmental monitoring transmission systems for measured values G08C
• CPC Class Codes: Y10S 977/731 formed from a single atom, molecule, or cluster
• CPC Class Codes: Y10S 977/773 Nanoparticle, i.e. structure having three dimensions of 100 nm or less
• CPC Class Codes: Y10S 977/956 Of mechanical property
• CPC Class Codes: Y10S 977/959 Of disease state

Abstract

Provided are compositions and systems useful in remote monitoring of chemical hazards, air quality, and medical conditions, for example, robotic systems to search for and detect explosives, mines, and hazardous chemicals. In addition, the methods, systems and compositions of the invention provide the ability to mine data from a database containing a plurality of chemical fingerprints.

Claims

1. A sensor array system for remote characterization of a gaseous or vapor sample, comprising:

a plurality of sensors, wherein at least one sensor is an electrically conductive sensor comprising alternating regions of a conductive material and a material compositionally different than the conductive material between two conductive leads, wherein the sensor provides an electrical path through the regions of the conductive material and the regions of the compositionally different material, wherein the plurality of sensors provide a detectable signal when contacted by an analyte;

a measuring apparatus, in communication with plurality of sensors capable of measuring the detectable signal;

a transmitting device, in communication with the measuring apparatus for transmitting information corresponding to the detectable signal to a remote location via the Internet, fiber optic cable, and/or an air-wave frequency; and

a computer comprising a resident algorithm capable of characterizing the analyte.

2. The system of claim 1, wherein the plurality of sensors further comprises a sensor selected from the group consisting of surface acoustic wave sensors, quartz crystal resonators, metal oxide sensors, dye-coated fiber optic sensors, dye-impregnated bead arrays, micromachined cantilever arrays, composites having regions of conducting material and regions of insulating organic material, composites having regions of conducting material and regions of conducting or semi-conducting organic material, chemically-sensitive resistor or capacitor films, metal-oxide-semiconductor field effect transistors, bulk organic conducting polymeric sensors, and any combination thereof.

3. The system of claim 1, wherein at least one sensor comprises regions of a conductive material and a conductive material compositionally different than the conductive material, wherein the sensor provides an electrical path through the regions of the conductive material and the regions of the compositionally different material, and wherein the conductivity changes upon adsorption with the analyte.

4. The system of claim 1, wherein at least one region of compositionally different material of one sensor is a different thickness than the region of compositionally different material of at least one other sensor.

5. The system of claim 1, wherein the compositionally different material is selected from the group consisting of polyanilines, an emeraldine salt of polyanilines, polypyrroles, polythiophenes, polyEDOTs, and derivatives thereof.

6. The system of claim 3, wherein the conductive material is selected from the group consisting of carbon black, Ag, Au, Pd, Cu, Ni, AuCu, and Pt.

7. The system of claim 5, wherein the at least one sensor further comprises an insulator or plasticizer.

8. The system of claim 3, wherein at least one other sensor comprises composites having regions of a conducting material and regions of a non-conducting organic material.

9. The system of claim 1, wherein the measuring apparatus converts the detectable signal to a digital representation of the detectable signal.

10. The system of claim 1, wherein the measuring apparatus converts the detectable signal to a digital profile representation of the detectable signal from each of the plurality of sensors.

11. The system of claim 1, wherein the sample is an environmental sample.

12. The system of claim 11, wherein the environmental sample is an air sample.

13. The system of claim 11, wherein the environmental sample is the headspace of a liquid sample.

14. The system of claim 1, wherein the sample is a biological sample.

15. The system of claim 14, wherein the biological sample is selected from the group consisting of a breath sample, a urine sample, a vaginal sample, a feces sample, a tissue sample and a blood sample.

16. The system of claim 14, wherein the biological sample is a breath sample.

17. The system of claim 1, wherein the data is analyzed by comparing the data to a database comprising a data profile from at least one previously-obtained detectable signal from a sample of known composition.

18. The system of claim 17, wherein the analyte in the sample is identified by matching the data to the data profile of a known composition in the database.

19. The system of claim 1, wherein the data is analyzed by comparing the data to a database containing data profiles from a plurality of detectable signals.

20. The system of claim 19, wherein each data profile in the database is associated with at least one identifier.

21. The system of claim 20, wherein the at least one identifier is selected from the group consisting of location, time, age, sex, disease state, temperature, sample source, sample type, organism, and ethnicity.

22. The system of claim 19, wherein the analyte is identified by a best match of the data to a data profile in the database and identifying any identifier associated with the data profile.

23. The system of claim 1, wherein the measuring apparatus is an electrical measuring device in electrical communication with the at least one sensor.

24. The system of claim 1, wherein the resident algorithm is a member selected from the group consisting of principal component analysis, Fisher linear analysis, neural networks, genetic algorithms, fuzzy logic, pattern recognition, and combinations thereof.

25. The system of claim 1, further comprising an information storage device coupled to the measuring apparatus and storing information in the information storage device.

26. The system of claim 23, wherein the measuring apparatus includes a digital-analog converter.

27. The system of claim 1, wherein the measuring apparatus is optimized to detect a member selected from the group consisting of electromagnetic energy, optical properties, resistance, capacitance, inductance, impedance and combinations thereof.

28. The system of claim 1, wherein the analyte is detected in an application which is a member selected from the group consisting of environmental toxicology, remediation, biomedicine, material quality control, food monitoring, agricultural monitoring, heavy industrial manufacturing, ambient air monitoring, worker protection, emissions control, product quality testing, oil/gas petrochemical applications, combustible gas detection, H₂S monitoring, hazardous leak detection, emergency response and law enforcement applications, explosives detection, utility and power applications, food/beverage/agriculture applications, freshness detection, fruit ripening control, fermentation process monitoring and control, flavor composition and identification, product quality and identification, refrigerant and fumigant detection, cosmetic/perfume applications, fragrance formulation, chemical/plastics/pharmaceuticals applications, fugitive emission identification, solvent recovery effectiveness, hospital/medical applications, anesthesia and sterilization gas detection, infectious disease detection, breath analysis and body fluids analysis.

29. The system of claim 1, wherein the at least one sensor comprises 2 or more electrically conductive sensors.

30. The system of claim 1, wherein the plurality of sensors are electrically conductive sensors.

31. A system, comprising:

a plurality of sensor arrays at different remote locations, wherein each sensor array comprises a plurality of sensors;

a plurality of measuring apparata, in communication with each of the plurality of sensor arrays, wherein a measuring apparatus is capable of measuring a detectable change in a sensor array;

a plurality of transmitting devices, in communication with each measuring apparatus for transmitting information corresponding to the detectable signal to a remote location;

a computer comprising a resident algorithm capable of characterizing the analyte based upon the detectable signal; and

a storage system at the remote location for storing and retrieving information related to the detectable signal.