Therapeutic light source and method

• US 6,645,230 B2
• Filed: 03/23/2001
• Issued: 11/11/2003
• Est. Priority Date: 03/23/2000
• Status: Expired due to Term

• Current Assignee: The Lotus Global Group, Inc.
• Original Assignee: Photo Therapeutics Limited (Gadsden Properties, Inc.)
• Inventors: Whitehurst, Colin
• Primary Examiner(s): Boles, Derek
• Application Number:
  US09/815,348
• Publication Number:
  US 20020029071A1
• Time in Patent Office: 963 Days
• Field of Search: 607/80, 607/88, 607/90, 607/92, 607/93
• US Class Current: 607/88
• CPC Class Codes: A61N 2005/005 for cooling the radiator
• CPC Class Codes: A61N 2005/0611 Vagina
• CPC Class Codes: A61N 2005/0636 Irradiating the whole body
• CPC Class Codes: A61N 2005/0642 Irradiating part of the body at a certain distance
• CPC Class Codes: A61N 2005/0644 Handheld applicators
• CPC Class Codes: A61N 2005/0645 Applicators worn by the patient
• CPC Class Codes: A61N 2005/0647 the applicator adapted to be worn on the head
• CPC Class Codes: A61N 2005/0652 Arrays of diodes
• CPC Class Codes: A61N 2005/0662 Visible light
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body
• CPC Class Codes: A61N 5/0613 Apparatus adapted for a specific treatment
• CPC Class Codes: A61N 5/0617 Hair treatment
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent

Abstract

A therapeutic light source, for example for photodynamic therapy (PDT), comprises an air-cooled array of LED'"'"'s (L_x,y), the air being vented in the vicinity of the array. The array may be mounted at the distal end of a hand piece suitable for invasive therapy. The LED'"'"'s may be coupled to a light guide (W, L). The emission spectra of the LED'"'"'s may be substantially limited to the range 550 to 660 nm, and preferably to one of the ranges 590 to 640 nm, 560 to 644 nm, 650 to 660 nm, and 550 to 570 nm. The therapeutic light source may comprise a non-planar array of light-emitting diodes L conforming with the shape of an external area to be treated or diagnosed. The therapeutic light source may comprise a non-planar array of independently switchable red and blue light-emitting diodes L_R, L_B, mounted on a flexible backing.

Claims

1. A light source for therapy or diagnosis of a patient, comprising a housing in the form of a trapezoid prism open at the base and having an upper inner surface carrying an array of light-emitting diodes.

2. A light source as claimed in claim 1, wherein at least one inner side face of the trapezoid prism is reflective.

3. A light source as claimed in claim 1, wherein at least one inner side face of the trapezoid prism carries a further array of light-emitting diodes.

9. A method of cosmetic treatment of a patient, comprising illuminating the treatment area with light from a light source as claimed in any one claims 1, 5, and 7.

10. A method as claimed in claim 9, including applying or administering a photosensitizing drug to the treatment area prior to the illuminating step.

11. A method as claimed in claim 10, for portwine stain removal, or hair restoration or removal.

12. A method as claimed in claim 9, for skin rejuvenation, wrinkle removal or biostimulation.

13. A method of medical treatment of a patient, comprising illuminating the treatment area with light from a light source as claimed in any one of claims 1, 4, 5, and 7.

14. A method as claimed in claim 13, including applying or administering a photosensitizing drug to the treatment area prior to the illuminating step.

15. A method as claimed in claim 14, for the treatment of one or more of actinic/solar keratoses, Bowen'"'"'s disease, superficial basal cell carcinoma, squamous cell carcinoma, intraepithelial carcinoma, mycosis fungoides, T-cell lymphoma, acne and seborrhoea, eczema, psoriasis, nevus sebaceous, gastrointestinal conditions (e.g. Barratt'"'"'s oesophagus and colorectal carcinomas), gynaecological disorders (e.g. VIN, CIN and excessive uterine bleeding), oral cancers (e.g. pre-malignant or dyplastic lesions and squamous cell carcinomas), viral infections such as herpes simplex, molluscum contagiosum, and warts (recalcitrant, verruca vulgaris or verruca plantaris), alopecia areata, or hirsutism.

4. A light source for therapy or diagnosis of a patient, comprising an intraluminal probe carrying on a substantially spherical surface thereof an array of discrete light-emitting diodes.

5. A therapeutic light source, comprising an array of light-emitting diodes arranged so that light from the light-emitting diodes is incident directly on a treatment field with an intensity of at least approximately 10 mW/cm² and a spatial intensity fluctuation of approximately 10% or less, and means for cooling the diodes by forced air convection.

6. A light source as claimed in claim 5, wherein the light-emitting diodes are thermally coupled to one or more heatsinks.

7. A therapeutic light source, comprising an array of light-emitting diodes arranged to give an output intensity of at least 10 mW/cm² in a treatment field, means for cooling the diodes by forced air convection, and a passage for carrying the air from a proximal end thereof to a distal end thereof, wherein the diodes are mounted at the distal end, the distal end is dimensioned so as to be locatable proximate a cervix such that light emitted by the light-emitting diode array is incident on the cervix, and the distal end is concave so as to fit over the cervix.

8. A light source as claimed in claim 7, including a fan mounted at the proximal end of the passage.