Dual stage microvalve and method of use
First Claim
Patent Images
1. A micro-machined drug delivery and biosensing device, for sensing a concentration of a chemical in a patient and administering drugs comprising:
- a. a substrate;
b. at least one drug delivery reservoir in said substrate, each said drug delivery reservoir having a first stage containing molecules and a second stage containing molecules, each said drug delivery reservoir further having a reservoir partition positioned between and separating said first stage and said second stage, each said reservoir having a reservoir cap positioned over said molecules in said second stage; and
c. at least one sensing reservoir in said substrate, each said sensing reservoir having a first stage containing molecules and a second stage containing molecules, said second stage of each said sensing reservoir having a pair of sensing electrodes and a reservoir cap positioned over said molecules in each said second stage, each said sensing reservoir further having a reservoir partition separating said first stage from said second stage.
2 Assignments
0 Petitions
Accused Products
Abstract
A micro-machined drug delivery device and method of use for the delivery of labile drugs is disclosed. A micro-machined sensing device and method of use is also disclosed. A micro-machined drug delivery and sensing device and method of use is additionally disclosed. All three devices are intended to be inserted into a patient'"'"'s body. The drug delivery devices allow for the mixing of drug components prior to the release of the mixture into the patient'"'"'s body where the mixture is labile. The micro-machined sensing device is suitable for monitoring the concentration of a specific chemical in a patient'"'"'s body fluids when the monitoring requires a labile reagent that must be mixed prior to introduction of the body fluid into the sensing device. The micro-machined drug delivery and sensing device is especially applicable in situations where the prompt delivery of labile drugs is necessary.
148 Citations
23 Claims
-
1. A micro-machined drug delivery and biosensing device, for sensing a concentration of a chemical in a patient and administering drugs comprising:
-
a. a substrate;
b. at least one drug delivery reservoir in said substrate, each said drug delivery reservoir having a first stage containing molecules and a second stage containing molecules, each said drug delivery reservoir further having a reservoir partition positioned between and separating said first stage and said second stage, each said reservoir having a reservoir cap positioned over said molecules in said second stage; and
c. at least one sensing reservoir in said substrate, each said sensing reservoir having a first stage containing molecules and a second stage containing molecules, said second stage of each said sensing reservoir having a pair of sensing electrodes and a reservoir cap positioned over said molecules in each said second stage, each said sensing reservoir further having a reservoir partition separating said first stage from said second stage. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
-
-
22. A method for sensing a concentration of a chemical in a patient'"'"'s body fluids comprising:
-
a. inserting a micro-machined sensing device into said patient, said micro-machine sensing device comprising;
i. a substrate;
ii. at least one reservoir in said substrate, said reservoir having a first stage containing molecules and a second stage containing molecules;
iii. a pair of sensing electrodes in said second stage of said reservoir, said sensing electrodes in electrical communication with control circuitry;
iv. a reservoir cap positioned on each said reservoir over said second molecules in said second stage; and
v. a reservoir partition separating said first stage from said second stage;
b. contacting said molecules in said first stage with said molecules in said second stage so as to form a sensing element by disintegrating said reservoir partition, said first stage and said second stage combining to form a volume;
c. permitting body fluid to enter said volume where said body fluid reacts with said sensing element to produce a signal detected by said sensing electrodes; and
d. sending said detected signal to control circuitry.
-
-
23. A method for sensing a concentration of a chemical in a patient'"'"'s body fluids and releasing drugs into the patient'"'"'s body, comprising:
-
a. inserting a micro-machined drug delivery and sensing device into said patient, said micro-machine sensing device comprising;
i. a substrate;
ii. at least one drug delivery reservoir in said substrate, each said drug delivery reservoir having a first stage containing molecules and a second stage containing molecules, each said drug delivery reservoir having a reservoir partition positioned between and separating said first and said second stage, each said reservoir having a reservoir cap positioned over said molecules in said second stage;
iii. at least one sensing reservoir in said substrate, said reservoir having a first stage containing molecules and a second stage containing molecules, a pair of sensing electrodes in said second stage of each said reservoir, said sensing electrodes in electrical communication with control circuitry, a reservoir cap positioned on each said reservoir over said second molecules in said second stage, a reservoir partition separating said first stage from said second stage; and
b. contacting said molecules in said first stage of said sensing reservoir with said molecules in said second stage of said sensing reservoir so as to form a sensing element by disintegrating said reservoir partition, said first stage and said second stage of said sensing reservoir combining to form a volume;
c. permitting body fluid to enter said volume where said body fluid reacts with said sensing element to produce a signal detected by said sensing electrodes;
d. sending said detected signal to control circuitry, said control circuitry sending a signal to at least one drug release reservoir in response to said detected signal received by said control circuitry;
e. contacting said molecules in said first stage of said drug release reservoir with said molecules in said second stage of said drug release reservoir so as to form a mixture; and
f. releasing said mixture from said micro-machined drug delivery system into said patient.
-
Specification
-
- Resources
Litigation Campaign Assessment
Thank you for your request. You will receive a custom alert email when the Litigation Campaign Assessment is available.
×
-
Current AssigneeOhio State University, University of Kentucky
-
Original AssigneeOhio State University, University of Kentucky
-
InventorsMadou, Marc J., Daunert, Sylvia
-
Primary Examiner(s)Mendez, Manuel
-
Assistant Examiner(s)Han, Mark K
-
Application NumberUS09/946,790Time in Patent Office833 DaysField of Search604/890.1, 604/891.1, 604/892.1, 604/65, 604/66, 604/131, 600/309, 600/345, 600/347, 600/348, 600/365US Class Current604/891.1CPC Class CodesA61K 9/0009 involving or responsive to ...A61K 9/0097 Micromachined devices; Micr...
