Preparation of virally inactivated intravenously injectable immune serum globulin

  • US 6,686,191 B1
  • Filed: 09/22/1995
  • Issued: 02/03/2004
  • Est. Priority Date: 09/22/1995
  • Status: Expired due to Fees
First Claim
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1. A method of treating a solution of antibodies which may have virus activity, the method comprisinga) contacting the solution with a trialkylphosphate and a detergent under conditions sufficient to substantially reduce any virus activity and resulting in an increased level of anticomplement activity;

  • and b) then incubating the solution of step a) under conditions of controlled time, pH, temperature, and ionic strength, such that the increased anticomplement activity of the solution is reduced to an acceptable level suitable for intravenous administration.

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