Method and device for physiologic analysis

• US 6,699,202 B1
• Filed: 11/03/2000
• Issued: 03/02/2004
• Est. Priority Date: 11/03/2000
• Status: Expired due to Term

• Current Assignee: IT Gambert GmbH
• Original Assignee: IT Gambert GmbH
• Inventors: Schubert, Peter, Wex, Kerstin, Gambert, Rudolf
• Primary Examiner(s): Nasser, Robert L.
• Assistant Examiner(s): MALLARI, PATRICIA C
• Application Number:
  US09/705,654
• Time in Patent Office: 1,215 Days
• Field of Search: 600/529, 600/531, 600/532, 600/533, 600/538, 73/233, 422/84, 436/900, 482/13, 128/204.22
• US Class Current: 600/532
• CPC Class Codes: A61B 5/0833 Measuring rate of oxygen consumption

Abstract

A new method and a device are disclosed to determine physiologic parameters of a subject by analyzing it'"'"'s breathing gas with an electrochemical sensor. The measured components of the breathing gas allow for many conclusions about the condition of the subjects'"'"'s pulmonary system. It is therefore an objective of this invention to determine physiologic parameters from measuring the partial pressure of oxygen in the mainstream of the breathing gas. According to the invention the measurement can be performed non invasive and allows for conclusions about the respiratory and metabolic system of a subject. The invention makes a continuous measurement of the oxygen partial pressure possible, that almost shows no time delay. The invention allows for instance the determination of parameters like the oxygen concentration in the breathing gas, the oxygen consumption of the subject, the heart frequency, the respiratory quotient, the compliance of the pulmonary tract and other physiologic parameters.

Claims

1. A method to determine physiological parameters from a breathing gas of a subject with an electrochemical sensor, the method comprising:

placing an oxygen sensor in a mainstream of the breathing gas that is capable of making one or more measurements of a partial pressure of oxygen during one or several breathing cycles with a response time of less than 200 milliseconds,

transmitting an electric sensor signal that is proportional to the oxygen partial pressure or shows a mathematical relation to the oxygen partial pressure to an electronic analyzer,

determining an oxygen partial pressure curve from the partial pressure of oxygen as a function of time; and

determining a physiologic parameter from the one or more measurements of the partial pressure of oxygen, wherein the step of determining a physiologic parameter comprises the step of determining an inspiratory and an expiratory oxygen partial pressure from the measured oxygen partial pressure values.

2. The method in accordance with claim 1, further comprising the step of determining further pulmonary and/or cardiopulmonary parameters from the analysis of the time course of the oxygen partial pressure curve for one or more breathing cycles.

3. The method in accordance with claim 1, further comprising the step of measuring a pressure of a breathing gas to determine an oxygen concentration of the breathing gas from the measured oxygen partial pressure and the known or measured pressure of the breathing gas.

4. The method in accordance with claim 1, further comprising the step of performing a measurement of expiratory breathing gas flow in addition to a measurement of the expiratory oxygen partial pressure and calculating an oxygen uptake of the subject per time or per ventilated volume.

5. The method in accordance with claim 4, further comprising the step of calculating an oxygen consumption of the subject from the oxygen uptake per time.

6. The method in accordance with claim 5, further comprising the step of determining an amount of expiratory carbon dioxide using another method, and determining metabolic and/or lung function and/or cardiac function parameters from the measured oxygen consumption and expiratory carbon dioxide amount.

7. The method in accordance with claim 1, further comprising the step of adding other gases from the group consisting of oxygen, carbon dioxide, carbon monoxide, helium or nitrogen to the breathing gas for a certain time, so that the subject breathes only the added gas for a certain time, and thereafter,when the subject then turns back to breath normal air, determining at least one of metabolic, lung function, or cardiac function parameters from the signal time characteristics of the expiratory oxygen partial pressure.

8. The method in accordance with claim 1, further comprising the step of determining a heart frequency of the subject by analyzing the oxygen partial pressure curve for one or several breathing cycles.

9. The method in accordance with claim 8, further comprising the step of determining the subject'"'"'s oxygen uptake by performing a measurement of expiratory breathing gas flow in addition to the measurement of the expiratory oxygen partial pressure and calculating the oxygen uptake of the subject per time or per ventilated volume and determing the subject'"'"'s oxygen pulse from its heart frequency and its oxygen uptake.

10. The method in accordance with claim 1, further comprising the step of determining at least one of metabolic, lung function and cardiac function parameters of a subject from an amplitude of pulsatory change in the oxygen partial pressure curve.

11. The method in accordance with claim 1, further comprising the step of determining a breathing frequency from the oxygen partial pressure curve.

12. A device for the determination of physiologic parameters consisting of an electrochemical oxygen sensor and an electronic analyzer, such that:

the sensor operates in a galvanic or potentiostatic mode;

a measurement is performed directly in a mainstream of a breathing gas;

the sensor measures an oxygen partial pressure with a response time of less than 200 milliseconds,

and transmits a signal that is proportional to the oxygen partial pressure or is related to it by a certain mathematical function to the electronic analyzer.

13. The device according to claim 12, wherein said analyzer includes of a processor or a microcontroller and a graphic display.