Osmotically stabilized microbubble preparations

  • US 6,706,253 B2
  • Filed: 05/21/2001
  • Issued: 03/16/2004
  • Est. Priority Date: 07/30/1993
  • Status: Expired due to Fees
First Claim
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1. A gas filled microbubble preparation stabilized by gas osmotic pressure, comprising:

  • a mixture of a first gas or gases and a second gas or gases wherein the second gas or gases act as a gas osmotic agent, wherein said first gas and said second gas are respectively present in a molar ratio of about 1;

    100 to about 1000;

    1, and wherein said first gas has a vapor pressure of at least about (760−

    x) mm Hg at 37°

    C., where x is the vapor pressure of the second gas at 37°

    C., and wherein said vapor pressure of each of said first and second gases is greater than about 75 mm Hg at 37°

    C., with the proviso that said first gas and said second gas are not water vapor.

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