Crystalline solids of carvedilol and processes for their preparation

  • US 6,710,184 B2
  • Filed: 01/15/2003
  • Issued: 03/23/2004
  • Est. Priority Date: 01/15/2002
  • Status: Expired due to Fees
First Claim
Patent Images

1. A process for preparing a crystalline solid of carvedilol Form II comprising the steps of:

  • heating crystalline carvedilol or a solvate thereof characterized by data selected from the group consisting of a PXRD pattern with peaks at about 6.5, 7.3, 16.0, and 30.5±

    0.2 degrees two-theta;

    a DSC thermogram with endothermic peaks at about 74°

    C. and 112°

    C.; and

    a FTIR spectrum with peaks at about 613, 740, 994, 1125, 1228, 1257, 1441, 1508, 1737, 2840, 3281, 3389, and 3470 cm

    1
    until the crystalline carvedilol is dry, mixing carvedilol Form II with the dry crystalline carvedilol, and storing the mixture for a holding time sufficient to transform the dry crystalline carvedilol into Form II.

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