Formulation of boronic acid compounds

  • US 6,713,446 B2
  • Filed: 01/25/2002
  • Issued: 03/30/2004
  • Est. Priority Date: 01/25/2001
  • Status: Expired due to Term
First Claim
Patent Images

1. A compound of the formula (1):

  • embedded imagewhereinP is hydrogen or an amino-group protecting moiety;

    R is hydrogen or alkyl;

    A is 0, 1, or 2;

    R1, R2, and R3 are each independently hydrogen, alkyl, cycloalkyl, aryl, or —



    R5, in each instance, is aryl, aralkyl, alkaryl, cycloalkyl, heterocyclyl, heteroaryl, or —


    R6, where W is a chalcogen and R6 is alkyl;

    wherein the ring portion of any said aryl, aralkyl, alkaryl, cycloalkyl, heterocyclyl, or heteroaryl in R1, R2, R3, or R5 can be optionally substituted; and

    Z1 and Z2 together form a moiety derived from a sugar, wherein the atom attached to boron in each case is an oxygen atom, and wherein the sugar is mannitol.

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