Devices for intraocular drug delivery

• US 6,719,750 B2
• Filed: 06/22/2001
• Issued: 04/13/2004
• Est. Priority Date: 08/30/2000
• Status: Expired due to Term

• Current Assignee: Johns Hopkins University
• Original Assignee: Johns Hopkins University
• Inventors: Humayun, Mark, Barnes, Aaron Christopher, Varner, Signe Erickson, DeJuan, Eugene Jr., Shelley, Terry
• Primary Examiner(s): Casler, Brian L.
• Assistant Examiner(s): Ghafoorian, Roz
• Application Number:
  US09/888,092
• Publication Number:
  US 20020026176A1
• Time in Patent Office: 1,026 Days
• Field of Search: 604/891.1, 604/521, 604/892.1, 604/528, 604/585, 604/890.1, 604/93.01, 604/288, 604/9-8, 604/143, 606/213, 606/198, 424/424-430, 128/898, 623/1.13, 600/405-561, 600/107
• US Class Current: 604/289
• CPC Class Codes: A61B 2017/00867 shape memory effect for prostheses A61F2210/0014
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants
• CPC Class Codes: A61P 27/02 Ophthalmic agents

Abstract

An therapeutic agent delivery device that can allows is particularly suitable for delivery of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. Preferred devices of the invention are minimally invasive, refillable and may be easily fixed to the treatment area. Preferred delivery devices of the invention also include those that comprise a non-linear shaped body member body housing one or more substances and a delivery mechanism for the sustained delivery of the one or more substances from the non-linear shaped body member to the patient.

Claims

1. A method for treating a patient comprising:

(a) providing a delivery device comprising a coil-shaped body member; and

(b) inserting into a patient eye the device whereby the coil-shaped body member is placed in the patient eye and a substance is delivered to the patient.

2. The method of claim 1 wherein a therapeutic agent is delivered to the patient eye.

3. The method of claim 2 wherein the substance delivered to the patient eye is chosen from one or more of an antibiotic, an antifungal, an antiviral, an antibacterial, an antiallergenic, an anti-inflammatory, a decongestant, a miotic or anti-cholinesterase, a mydriatic, a sympathomimetic, an antineoplastic, a hormonal agent, a beta adrenergic blocker, a growth factor, a carbonic anhydrase inhibitor, an angiogenesis inhibitor, a prostaglandin or an antiprostaglandin.

4. The method of claim 1 or 2 wherein the device body member comprises a polymer.

5. The method of claim 1 wherein the device body member comprises a polymer that comprises a therapeutic substance to be delivered to the patient eye.

6. The method of claim 1 wherein the device comprises a cap element that mates against patient eye outer surface while the body member is inserted into the eye.

7. The method of claim 1 wherein the device comprises a shape memory material.

8. A method for treating a patient comprising:

(a) providing a delivery device comprising a non-linear shaped body member having at least two deviations from a linear path and that has a shape other than a substantially C-configuration; and

(b) inserting into a patient eye the device whereby the body member resides in the patient eye and a substance is administered to the patient.

9. The method of claim 8 wherein the device body member comprises at least three deviations from a linear path.

10. The method of claim 8 wherein the device body member comprises at least four deviations from a linear path.

11. The method of claim 8 wherein the device body member comprises at least five deviations from a linear path.

12. The method of claim 8 wherein the device body member comprises a helical shape.

13. The method of claim 8 wherein the device body member comprises a substantially Z-shape.

14. The method of claim 13 wherein the substance administered to the patient eye is chosen from one or more of an antibiotic, an antifungal, an antiviral, an antibacterial, antiallergenic, an anti-inflammatory, a decongestant, a miotic or anti-cholinesterase, a mydriatic, a sympathomimetic, an antineoplastic, a hormonal agent, a beta adrenergic blocker, a growth factor, a carbonic anhydrase inhibitor, an angiogenesis inhibitor, a prostaglandin or an antiprostaglandin.

15. The method of claim 8 wherein the device body member comprises a polymer.

16. The method of claim 8 wherein the device body member comprises a polymer that comprises a therapeutic substance to be delivered to the patient eye.

17. The method of claim 8 wherein the device comprises a cap element that mates against patient eye outer surface while the body member is inserted into the eye.

18. The method of claim 8 wherein the device comprises a shape memory material.

19. An implantable ocular drug delivery device comprising:

a) a coil-shaped body member that is implanted within a patient eye during use of the device to deliver a drug substance to the patient eye;

b) a cap element that mates against the patient eye outer surface while the body member is inserted to the eye.

20. The device of claim 19 wherein the device comprises a therapeutic agent for delivery to the patient eye during use of the device.

21. The device of claim 19 wherein the cap element mates the body member at a proximal end of the device.

22. The device of claim 19 wherein the device body member comprises a polymer.

23. The device of claim 19 wherein the device body member comprises a polymer that comprises a therapeutic substance to be delivered to the patient eye.