Use of mometasone furoate for treating upper airway diseases

• US 6,723,713 B2
• Filed: 04/30/2003
• Issued: 04/20/2004
• Est. Priority Date: 01/27/1994
• Status: Expired due to Fees

• Current Assignee: Merck Sharp & Dohme Corporation (Merck & Co., Inc.)
• Original Assignee: Schering Corporation (Merck & Co., Inc.)
• Inventors: Nolop, Keith B., Cuss, Francis M., Chaudry, Imtiaz A., Cayen, Mitchell, Patrick, James E., Nagabhushan, Nagamani, Sequeira, Joel A.
• Primary Examiner(s): CLARDY, S
• Application Number:
  US10/426,329
• Publication Number:
  US 20030216365A1
• Time in Patent Office: 356 Days
• Field of Search: 514/169, 514/172, 514/176, 514/182, 514/826, 514/958
• US Class Current: 514/169
• CPC Class Codes: A61K 31/57 substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
• CPC Class Codes: A61K 31/58 containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin digitoxin A61K31/7048
• CPC Class Codes: A61K 9/0043 Nose
• CPC Class Codes: A61K 9/0075 for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
• CPC Class Codes: A61K 9/008 comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 11/02 Nasal agents, e.g. decongestants
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 37/08 Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14

Abstract

The administration of aerosolize particles of mometasone furoate in the form of dry powders, solutions, or aqueous suspension for treating corticosteroid-responsive diseases of the surfaces of upper and/or lower airway passages and/or lungs, e.g., allergic rhinitis and asthma is disclosed.

Claims

1. A method of treating allergic rhinitis comprising administering once daily nasal passages 200 micrograms of mometasone furoate.

2. The method of claim 1, wherein the mometasone furoate is administered as anhydrous mometasone furoate.

3. The method of claim 1, wherein the mometasone furoate is administered as mometasone furoate monohydrate.

4. The method of claim 1, wherein the mometasone furoate is administered in the form of an aqueous suspension.

5. The method of claim 1, wherein the mometasone furoate is administered in the form of an aqueous suspension of mometasone furoate monohydrate.

6. The method of claim 1, wherein the mometasone furoate is administered in the form of an aqueous suspension of anhydrous mometasone furoate.

7. The method of claim 1, wherein there are administered 200 micrograms of mometasone furoate by applying twice to each nostril about 50 micrograms of mometasone furoate.

8. A method of treating a disease comprising allergic rhinitis, comprising administering once daily to nasal passages an aqueous nasal spray comprising mometasone furoate monohydrate, in an amount providing about 100 micrograms of mometasone furoate to each nostril.

9. The method of claim 8, wherein there are administered 200 micrograms of mometasone furoate by applying twice to each nostril about 50 micrograms of mometasone furoate.

10. A method of treating a disease comprising allergic rhinitis, comprising administering once daily to nasal passages an aqueous nasal spray comprising mometasone furoate monohydrate, in an amount providing about 50 micrograms of mometasone furoate to each nostril.