Non-invasive tissue glucose level monitoring

• US 6,728,560 B2
• Filed: 02/28/2002
• Issued: 04/27/2004
• Est. Priority Date: 04/06/1998
• Status: Expired due to Fees

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Freeman, Jenny E., Tian, Wei Dong, Kollias, Nikiforos
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US10/084,984
• Publication Number:
  US 20020082487A1
• Time in Patent Office: 789 Days
• Field of Search: 600/316, 600/319, 600/347, 600/365, 600/317, 128/903
• US Class Current: 600/316
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: Y10S 128/903 Radio telemetry

Abstract

Instruments and methods for performing non-invasive measurements of analyte concentrations and for monitoring, analyzing and regulating tissue status, such as tissue glucose levels.

Claims

1. A nocturnal glucose monitor, comprising:

a non-invasive glucose measurement probe for detecting glucose levels of a juvenile patient,

an alarm unit responsive to the glucose measurement probe, the alarm unit being operative to detect excursions of glucose values outside of a predetermined juvenile nocturnal glucose range for a diabetic patient and to produce a parental alarm signal in response to detected excursions,

an audio transducer responsive to the alarm signal, and

a remote transmitter responsive to the non-invasive glucose measurement probe and a receiver responsive to the remote transmitter, wherein the audio transducer is responsive to the remote transmitter.

2. The nocturnal glucose monitor of claim 1 wherein the remote transmitter is a wireless transmitter and the receiver is a wireless receiver.

3. The nocturnal glucose monitor of claim 2 wherein the glucose measurement probe is a fluorescence-based probe.

4. The nocturnal glucose monitor of claim 1 wherein the glucose measurement probe is a fluorescence-based probe.

5. A nocturnal glucose monitoring method, comprising:

providing a non-invasive glucose measurement probe such that it is responsive to a glucose level of a child during nighttime sleep,

detecting excursions of glucose values outside of a predetermined nocturnal glucose range for a diabetic child during nighttime sleep of the child, and

causing a remote receiver to issue an audible alarm to a parent of the child in response to the step of detecting.

6. The method of claim 5 wherein the step of causing operates based on wireless transmission.

7. The method of claim 6 wherein the step of detecting operates based on fluorescence.

8. The method of claim 5 wherein the step of detecting operates based on fluorescence.