Method for determination of analytes using NIR, adjacent visible spectrum and discrete NIR wavelenths
First Claim
1. A method for determining a concentration of a constituent in a tissue of a subject comprising the steps of:
- irradiating the tissue with a broad spectrum of radiation in the AV and NIR region from a first source of radiation;
irradiating the tissue with radiation in the longer wavelength NIR region from a second source of radiation;
measuring with a detector transmitted or radiation from the tissue at a continuum of wavelengths in the AV and NIR region and at one, or more than one discrete wavelength in the longer wavelength NIR region, wherein the continuum of wavelengths in the AV and NIR region is between 500 and 1100 nm, and wherein the one, or more than one discrete wavelength is between 1590 and 1700 nm; and
calculating the concentration of the constituent on the basis of the measurements, thereby determining the concentration of the constituent in the tissue, wherein said first and second sources are approximately oppositely disposed to said detector.
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Abstract
Described is a method for measuring the concentration of a blood constituent within a body part (80) of a living subject which comprises irradiating a body part of the subject with a continuum of a broad spectrum of radiation in adjacent and near infrared range of the electomagnetic spectrum; collecting the band of radiation after the radiation has been directed onto the part; dispersing the continuum of collected radiation into a dispersed spectrum of component wavelengths onto a detector (120) the detector taking measurements of at least one of transmitted or reflected radiation from the collected radiation; and transferring the measurements to a processor (300), and then measuring the same kind of absorbance or reflectance with respect to one or more a discrete wavelengths of radiation from the longer near infrared range and using the measurements to calculate the concentration of the constituent.
232 Citations
38 Claims
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1. A method for determining a concentration of a constituent in a tissue of a subject comprising the steps of:
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irradiating the tissue with a broad spectrum of radiation in the AV and NIR region from a first source of radiation;
irradiating the tissue with radiation in the longer wavelength NIR region from a second source of radiation;
measuring with a detector transmitted or radiation from the tissue at a continuum of wavelengths in the AV and NIR region and at one, or more than one discrete wavelength in the longer wavelength NIR region, wherein the continuum of wavelengths in the AV and NIR region is between 500 and 1100 nm, and wherein the one, or more than one discrete wavelength is between 1590 and 1700 nm; and
calculating the concentration of the constituent on the basis of the measurements, thereby determining the concentration of the constituent in the tissue, wherein said first and second sources are approximately oppositely disposed to said detector. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method for measuring concentration of a blood constituent within a body part of a living subject comprising:
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irradiating a body part of the subject with a broad spectrum of radiation in the AV and NIR region from a first source of radiation;
collecting the radiation from the AV and NIR region after the radiation has been directed onto the part, wherein the collected radiation comprises a band of radiation from 500 to 1100 nm;
dispersing the collected radiation into a dispersed spectrum of component wavelengths onto a detector, the detector taking measurements transmitted and radiation from the collected radiation;
transferring the measurements to a processor;
irradiating the body part of the subject with radiation in the longer wavelength NIR region from a second source of radiation;
detecting with the detector one, or more than one discrete wavelength in the longer wavelength NIR region after the radiation has been directed onto the part, wherein the one, or more than one discrete wavelength is between 1590 and 1700 nm, the detector taking measurements of transmitted and reflected radiation; and
transferring the measurements to a processor;
based on the measurements and one or more calibration algorithms, the processor calculating the concentration of said constituent of said blood, wherein said first and second sources are approximately oppositely disposed to said detector.- View Dependent Claims (11, 12, 13, 14)
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15. A method for measuring concentration of a blood constituent within a body part of a living subject comprising:
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irradiating the body part of the subject with a first continuum of a broad spectrum band of radiation in the AV and NIR region from a first source of radiation;
collecting the first band of radiation after the radiation has been directed onto the part, wherein the first band of radiation collected is between 500 and 1100 nm;
dispersing the continuum of collected radiation into a dispersed spectrum of component wavelengths onto a detector, the detector taking measurements of transmitted and radiation from the collected radiation; and
transferring the measurements to a processor;
irradiating the body part of the subject with a second continuum of a radiation band in the longer wave NIR region from a second source of radiation;
collecting the second band of radiation after the radiation has been directed onto the part;
dispersing the continuum of collected radiation into a dispersed spectrum of component wavelengths onto the detector;
detecting with the detector one, or more than one discrete wavelengths in the longer wavelength NIR region with the detector, wherein the one, or more than one discrete wavelength is between 1590 and 1700 nm, the detector taking measurements of transmitted and radiation from the collected radiation; and
transferring the measurements to a processor based on the measurements and one or more calibration algorithms, the processor calculating the concentration of said constituent of said blood, wherein said first and second sources are approximately oppositely disposed to said detector. - View Dependent Claims (16, 17, 18, 19)
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20. A method for determining a concentration of a constituent in a tissue of a subject comprising the steps of:
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irradiating the tissue with a broad spectrum of radiation in the AV and NIR region from a first source of radiation;
irradiating the tissue with radiation in the longer wavelength NIR region from a second source of radiation, measuring with a detector transmitted or radiation from the tissue at a continuum of wavelengths in the AV and NIR region, at one, or more than one discrete wavelength between 1100 and 1300 nm, and at one, or more than one discrete wavelength between 1590 and 1700 nm, wherein the continuum of wavelengths in the AV and NIR region is between 500 and 1100 nm; and
calculating the concentration of the constituent on the basis of the measurements, thereby determining the concentration of the constituent in the tissue, wherein the first and second sources are approximately oppositely disposed to said detector. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28)
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29. A method for measuring concentration of a blood constituent within a body part of a living subject comprising:
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irradiating a body part of the subject with a broad spectrum of radiation in the AV and NIR region from a first source of radiation;
collecting the radiation from the AV and NIR region after the radiation has been directed onto the part, wherein the collected radiation comprises a band of radiation between 500 and 1100 nm;
dispersing the collected radiation into a dispersed spectrum of component wavelengths onto a detector, the detector taking measurements of transmitted and radiation from the collected radiation;
transferring the measurements to a processor;
irradiating the body part of the subject with radiation in the longer wavelength NIR region from a second source of radiation;
detecting with the detector one, or more than one discrete wavelength between 1100 and 1300 nm, and one, or more than one discrete wavelength between 1590 and 1700 nm with a detector, the detector taking measurements of transmitted and radiation; and
transferring the measurements to a processor;
based on the measurements and one or more calibration algorithms, the processor calculating the concentration of said constituent of said blood,wherein the first and second sources are approximately oppositely disposed to said detector. - View Dependent Claims (30, 31, 32, 33)
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34. A method for measuring concentration of a blood constituent within a body part of a living subject comprising:
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irradiating the body part of the subject with a first continuum of a broad spectrum band of radiation in the AV and NIR region from a first source of radiation;
collecting the first band of radiation after the radiation has been directed onto the part, wherein the first band of radiation collected is between 500 and 1100 nm;
dispersing the continuum of collected radiation into a dispersed spectrum of component wavelengths onto a detector, the detector taking measurements transmitted and radiation from the collected radiation; and
transferring the measurements to a processor;
irradiating the body part of the subject with a second continuum of a radiation band in the longer wave NIR region from a second source of radiation;
collecting the second band of radiation after the radiation has been directed onto the part;
dispersing the continuum of collected radiation into a dispersed spectrum of component wavelengths onto the detector;
detecting with the detector one, or more than one discrete wavelength between 1100 and 1300 nm, and one, or more than one discrete wavelength between 1590 and 1700 nm with a detector, the detector taking measurements of transmitted and radiation; and
transferring the measurements to a processor based on the measurements and one or more calibration algorithms, the processor calculating the concentration of said constituent of said blood, wherein said first and second sources are approximately oppositely disposed to said detector. - View Dependent Claims (35, 36, 37, 38)
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Specification