Ventilatory stabilization technology

• US 6,752,150 B1
• Filed: 02/03/2000
• Issued: 06/22/2004
• Est. Priority Date: 02/04/1999
• Status: Expired due to Fees

• Current Assignee: University Technologies International, Inc.
• Original Assignee: University Technologies International, Inc.
• Inventors: Remmers, John E., Platt, Ronald S., Hajduk, Eric A.
• Primary Examiner(s): Lo, Weilun
• Assistant Examiner(s): MITCHELL, TEENA KAY
• Application Number:
  US09/498,504
• Time in Patent Office: 1,601 Days
• Field of Search: 128/204.18, 128/204.21, 128/204.23, 128/204.26, 128/205.23, 128/202.22
• US Class Current: 128/204.18
• CPC Class Codes: A61M 16/0009 with sub-atmospheric pressure, e.g. during expiration
• CPC Class Codes: A61M 16/0045 Means for re-breathing exhaled gases, e.g. for hyperventilation treatment
• CPC Class Codes: A61M 16/0069 the speed thereof being controlled by respiratory parameters, e.g. by inhalation
• CPC Class Codes: A61M 16/024 including calculation means, e.g. using a processor
• CPC Class Codes: A61M 16/085 Gas sampling
• CPC Class Codes: A61M 2016/0036 in the breathing tube and used in both inspiratory and expiratory phase
• CPC Class Codes: A61M 2016/0042 in the expiratory circuit
• CPC Class Codes: A61M 2016/103 the CO2 concentration
• CPC Class Codes: A61M 2230/432 partial CO2 pressure (P-CO2)

Abstract

A system for reducing central sleep apnea (CSA) is described in which certain methods of increasing a patient'"'"'s rebreathing during periods of the sleep cycle are used. By increasing rebreathing during periods of overbreathing, the over-oxygenation which typically results from the overbreathing period can be reduced, thus reducing the compensating underbreathing period and effectively reducing the loop gain associated with the central sleep apnea.

Claims

1. An apparatus for treating central sleep apnea comprising:

a gas supplying means; and

a mask adapted to be fit on a patient'"'"'s face, the mask operably connected using a tube to the gas supplying means, the mask having an exit, wherein the apparatus is arranged such that during periods of increased breathing associated with central sleep apnea, some exhaled gasses from the patient flow retrograde into the tube towards the gas supplying means and away from the exit;

wherein the apparatus is adapted such that during an initial exhale portion of increased breathing associated with central sleep apnea, some exhaled gasses from the patient flow retrograde into the tube towards the gas supplying means and away from the exit and wash flow out of the tube such that during a next inhale portion a sufficient amount of rebreathing occurs to control central sleep apnea.

2. The apparatus of claim 1, wherein the apparatus is adapted such that during normal breathing periods little rebreathing occurs.

3. The apparatus of claim 2, wherein the apparatus is adapted such that during normal breathing periods some retrograde flow occurs but wash flow is sufficient to remove exhaled air before a next inhale portion.

4. The apparatus of claim 1, wherein the retrograde flow into the tube is influenced by gas pressure from the gas supplying means and by an exit hole size.

5. The apparatus of claim 1, wherein the exit hole size is adjustable.

6. The apparatus of claim 1, wherein pressure in the mask is set high enough to treat obstructive sleep apnea.

7. The apparatus of claim 1 wherein the gas-supplying means comprises a blower which blows air to the mask.

8. The apparatus of claim 1 wherein the mask is adapted to fit about a patient'"'"'s nose.

9. The apparatus of claim 1 wherein die gas-supplying means is adjustable.

10. The apparatus of claim 1, wherein gas pressure from the gas supplying means is set below four cm H₂O pressure.

11. The apparatus of claim 1, wherein gas pressure from the gas supplying means is set at two cm H₂O pressure or below.

12. The apparatus of claim 1 in which the mask comprises a dental appliance.

13. An apparatus for treating central sleep apnea comprising:

a gas supplying means; and

a mask adapted to be fit on a patient'"'"'s face, the mask operably connected using a tube to the gas supplying means, the mask having an exit, wherein the apparatus is arranged such that during periods of increased breathing associated with central sleep apnea, some exhaled gasses from the patient flow retrograde into the tube towards the gas supplying means and away from the exit, wherein gas pressure from the gas supplying means is set at a controlled level below four cm H₂O pressure independently of the respiratory cycle of the patient.

14. The apparatus of claim 13, wherein gas pressure from the gas supplying means is set at two cm H₂O pressure or below.

15. The apparatus of claim 13 in which the mask comprises a dental appliance.

16. A method of treating a patient suffering from central sleep apnea, the method comprising:

providing an apparatus comprising a gas supplying means and a mask adapted to be fit on the patient'"'"'s face, the mask operably connected using a tube to the gas supplying means, the mask having an exit;

fitting the mask to the patient'"'"'s face; and

adjusting the apparatus such that during periods of increased breathing associated with central sleep apnea, some exhaled gasses from the patient flow retrograde into the tube, wherein the adjusting step is done such that during an initial exhale portion of increased breathing associated with central sleep apnea, some exhaled gasses from the patient flow retrograde into the tube and wash flow out of the tube such that during a next inhale portion some rebreathing occurs sufficient to treat central sleep apnea.

17. The method of claim 16, wherein the adjusting step is done such that during normal breathing periods little rebreathing occurs.

18. The method of claim 17, wherein the adjusting step is done such that during normal breathing periods some retrograde flow occurs but wash flow is sufficient to remove exhaled air before a next inhale portion.

19. The method of claim 16, wherein the retrograde flow into the tube is influenced by gas pressure from the gas supplying means and by an exit hole size.

20. The method of claim 16, wherein the adjusting step includes adjusting an exit hole size.

21. The method of claim 16, wherein pressure in the mask is set high enough to treat obstructive sleep apnea.

22. The method of claim 16, wherein the gas supplying means comprises a blower.

23. The method of claim 16 wherein the mask is fitted about a patient'"'"'s nose.

24. The method of claim 16, wherein the adjusting step is such that gas pressure from the gas supplying means is set below four cm H₂O pressure.

25. The method of claim 16, wherein the adjusting step is such that gas pressure from the gas supplying means is set at two cm H₂O pressure or below.

26. The method of claim 16 in which the mask comprises a dental appliance.

27. A method of treating a patient suffering from central sleep apnea, the method comprising:

providing an apparatus comprising a gas supplying means and a mask adapted to be fit on the patient'"'"'s face, the mask operably connected using a tube to the gas supplying means, the mask having an exit;

fitting the mask to the patients face; and

adjusting the apparatus such that during periods of increased breathing associated with central sleep apnea, some exhaled gasses from the patient flow retrograde into the tube wherein the adjusting step is such that gas pressure from the gas supplying means is set at a level below four cm H₂O pressure independently of the respiratory cycle of the patient.

28. The method of claim 27, wherein the adjusting step is such that gas pressure from the gas supplying means is set at two cm H₂O pressure or below.

29. The method of claim 27 in which the mask comprises a dental appliance.

30. An apparatus for treating central sleep apnea comprising:

a gas supplying means;

a mask adapted to be fit on a patient'"'"'s face, the mask operably connected using an input tube to the gas supplying means, the mask having an exit;

a variable air resistance means operably connected to the exit of the mask; and

a controller operably connected to the variable air resistance means to adjust a level of rebreathing that occurs and maintains a temporally variable flow of air in the input tube without producing significant deviations in mask pressure.

31. The apparatus of claim 30 wherein the variable air resistance means comprises an adjustable valve.

32. The apparatus of claim 31 further comprising an exit tube between the mask and the adjustable valve.

33. The apparatus of claim 30 wherein the controller adjusts the variable air resistance means to provide a dead space during certain portions of a sleep cycle.

34. The apparatus of claim 30 wherein the controller adjusts the variable air resistance means to modify exit flow out of the mask at different times during a nights sleep.

35. The apparatus of claim 30 further comprising a flow meter to provide signals to the controller.

36. The apparatus of claim 30 wherein the controller detects periodicities in sleep cycle to determine how to adjust the level of rebreathing.

37. The apparatus of claim 30 in which the mask comprises a dental appliance.

38. An apparatus for treating central sleep apnea comprising:

a gas supplying means;

a mask adapted to be fit on a patient'"'"'s face, the mask incorporating a dental appliance to reduce mouth leaks, the mask operably connected using a tube to the gas supplying means; and

a processor adapted to adjust a level of rebreathing to control central sleep apnea in the patient by adjusting an active control element of the apparatus, wherein the active control element is selected from the group consisting of (1) a variable air resistance means operably connected to an exit of the mask, (2) a recirculator, and (3) a valve to a dead space volume.

39. The apparatus of claim 38, wherein the active control element is a unit to adjust a blower output.

40. The apparatus of claim 39, wherein the active control element is a unit to adjust a blower output revolutions per minute.

41. The apparatus of claim 38, wherein the active control element is adjusted during a periodic sleep cycle of the patient.

42. The apparatus of claim 38, wherein the active control element is adjusted over an entire sleeping period.

43. The apparatus of claim 38, wherein the processor receives data from a flow meter.

44. The apparatus of claim 38, wherein the processor receives data from a carbon dioxide sensor.

45. An apparatus for treating central sleep apnea comprising:

a gas supplying means;

a mask adapted to be fit on a patient'"'"'s face, the mask incorporating a dental appliance to reduce mouth leaks, the mask operably connected using a tube to the gas supplying means;

a processor adapted to adjust a level of rebreathing to control central sleep apnea in the patient by adjusting an active control element of the apparatus; and

an exit tube connected to the mask.

46. An apparatus for treating central sleep apnea comprising:

a blower; and

a mask adapted to be fit on a patient'"'"'s face, the mask operably connected using a tube to the blower, the mask having an exit, tile resistance of the exit being set that during treatment of central sleep apnea in the patient, expiratory air from the patient flows through the tube towards the blower and away from the exit, wherein the apparatus is arranged such that a gas flow from the blower is less than that used to treat obstructive sleep apnea.

47. The apparatus of claim 46, wherein gas pressure from the blower is set at four cm H₂O pressure or below.

48. The apparatus of claim 47, wherein gas pressure from the blower is set at two cm H₂O pressure or below.

49. The apparatus of claim 46, wherein the apparatus is arranged such that during periods of increased breathing associated with central sleep apnea, some exhaled gasses from the patient flow retrograde into the tube.

50. The apparatus of claim 49, wherein the apparatus is adapted such that during an initial exhale portion of increased breathing associated with central sleep apnea, some exhaled gasses from the patient flow retrograde into the tube and wash flow out of the tube such that during a next inhale portion some rebreathing occurs.

51. The apparatus of claim 49, wherein the apparatus is adapted such that during normal breathing periods little rebreathing occurs.

52. The apparatus of claim 49, wherein the apparatus is adapted such that during normal breathing periods some retrograde flow occurs but wash flow is sufficient to remove exhaled air before a next inhale portion.

53. The apparatus of claim 46 wherein the blower is adjustable.

54. A method of treating a patient suffering from central sleep apnea, the method comprising:

providing an apparatus comprising a blower and a mask adapted to be fit on the patient'"'"'s face, the mask operably connected using a tube to the blower, the mask having an exit;

fitting the mask to the patient'"'"'s face; and

adjusting the apparatus such that gas flow from the blower is controlled at a variable flow rate and essentially constant pressure, the pressure being less than that used to treat obstructive sleep apnea, in order to treat central sleep apnea in the patient, and such that during periods of increased breathing associated with central sleep apnea, some exhaled gasses from the patient flow retrograde into the tube.

55. The method of claim 54, wherein the adjusting step is such that gas pressure from the blower is set below four cm H₂O pressure.

56. The method of claim 55, wherein the adjusting step is such that gas pressure from the blower is set at two cm H₂O pressure or below.

57. The method of claim 54, wherein the adjusting step is done such that during an initial exhale portion of increased breathing associated with central sleep apnea, some of the patient'"'"'s exhaled gasses flow retrograde into the tube and wash flow out of the tube such that during a next inhale portion some rebreathing occurs.

58. The method of claim 54, wherein the adjusting step is done such that during normal breathing periods little rebreathing occurs.

59. Te method of claim 58, wherein the adjusting step is done such that during normal breathing periods some retrograde flow occurs but wash flow is sufficient to remove the exhaled air before a next inhale portion.

60. The method of claim 54, wherein the retrograde flow into the tube is influenced by gas pressure from the blower and by an exit hole size.

61. The method of claim 54 in which the mask comprises a dental appliance.

62. A method comprising:

providing an apparatus comprising a blower and a mask adapted to be fit on a patient'"'"'s face, the mask operably connected using a tube to the blower, the mask having an exit;

fitting the mask to the patient'"'"'s face;

detecting central sleep apnea in the patient; and

adjusting the apparatus to treat central sleep apnea, wherein the adjusting step is such that during periods of increased breathing associated with central sleep apnea, some exhaled gasses flow from the patient retrograde into the tube.

63. The method of claim 62, wherein the adjusting step comprises adjusting the apparatus such that gas flow from the blower is less than that used to treat obstructive sleep apnea to treat central sleep apnea in the patient.

64. The method of claim 62, wherein the adjusting step is such that gas pressure from the blower is set below four cm H₂O pressure.

65. The method of claim 64, wherein the adjusting step is such that gas pressure from the blower is set at two cm H₂O pressure or below.

66. The method of claim 63, wherein the adjusting step is done such that during an initial exhale portion of increased breathing associated with central sleep apnea, some of the patient'"'"'s exhaled gasses flow retrograde into the tube towards the blower and away from the exit and wash flow out of the tube such that dining a next inhale portion some rebreathing occurs.

67. The method of claim 63, wherein the adjusting step is done such that during normal breathing periods little rebreathing occurs.

68. The method of claim 67, wherein the adjusting step is done such that during normal breathing periods some retrograde flow occurs but wash flow is sufficient to remove exhaled air before a next inhale portion.

69. The method of claim 62, wherein the retrograde flow into the tube is influenced by gas pressure from the blower and by a size of an exit hole size, and gas flow rate from the blower is varied without significantly affecting mask pressure.

70. The method of claim 62, further comprising an obstructive sleep apnea treating step.

71. The method of claim 70, wherein the obstructive sleep apnea treating step occurs before the adjusting step.

72. A method comprising:

providing an apparatus comprising a blower and a mask adapted to be fit on a patient'"'"'s face, the mask operably connected using a tube to the blower, the mask having an exit, the resistance of the exit being set that during treatment of central sleep apnea in the patient, expiratory air from the patient flows through the tube towards the blower and away from the exit;

fitting the mask to the patient'"'"'s face;

treating an obstructive sleep apnea with the apparatus;

adjusting the apparatus to treat central sleep apnea; and

treating obstructive sleep apnea with the apparatus.

73. The method of claim 72, wherein the adjusting step comprises adjusting the apparatus such that gas flow from the blower is less than that used to treat obstructive sleep apnea to treat central sleep apnea in the patient.

74. The method of claim 72, wherein the adjusting step is such that gas pressure from the blower is set below four cm H₂O pressure.

75. The method of claim 74, wherein the adjusting step is such that gas pressure from the blower is set at two cm H₂O pressure or below.

76. The method of claim 72 wherein the adjusting step is such that during periods of increased breathing associated with central sleep apnea, some of the patient'"'"'s exhaled gasses flow retrograde into the tube.

77. The method of claim 76, wherein the adjusting step is done such that during an initial exhale portion of increased breathing associated with central sleep apnea, some exhaled gasses from the patient flow retrograde into the tube and wash flow out of the tube such that during a next inhale portion some rebreathing occurs.

78. The method of claim 76, wherein the adjusting step is done such that during normal breathing periods little rebreathing occurs.

79. The method of claim 78, wherein the adjusting step is done such that during normal breathing periods some retrograde flow occurs but wash flow is sufficient to remove exhaled air before a next inhale portion.

80. The method of claim 72, wherein the retrograde flow into the tube is influenced by gas pressure from the blower and by a size of the exit hole.

81. The method of claim 72, wherein the obstructive sleep apnea treating step comprises supplying blower pressure greater than eight cm H₂O.

82. The method of claim 72, wherein the obstructive sleep apnea treating step occurs before the adjusting step.