Therapeutic formulation for administering tolterodine with controlled release

  • US 6,770,295 B1
  • Filed: 08/09/2000
  • Issued: 08/03/2004
  • Est. Priority Date: 08/27/1998
  • Status: Expired due to Term
First Claim
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1. A method of treating unstable or overactive urinary bladder, wherein the method comprises administering to a patient in need of such treatment tolterodine, its 5-hydroxymethyl metabolite or the racemate corresponding to tolterodine, or a pharmaceutically acceptable salt thereof, in a pharmaceutically effective amount thereof through a controlled release formulation capable of maintaining a substantially constant serum level of the active moiety or moieties for at least 24 hours, wherein the 24-hour serum profile, expressed as the AUC of unbound tolterodine and 5-hydroxymethyl metabolite, is from 5 to about 150 nM*h.

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