Prevention and treatment of amyloidogenic disease
First Claim
Patent Images
1. A composition comprising an Aβ
- fragment linked to a tetanus toxoid carrier molecule to form a conjugate and an adjuvant, wherein the adjuvant enhances an immune response comprising antibodies to the Aβ
fragment.
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Abstract
The invention provides compositions and methods for treatment of amyloidogenic diseases. Such methods entail administering an agent that induces a beneficial immune response against an amyloid deposit in the patient. The methods are particularly useful for prophylactic and therapeutic treatment of Alzheimer'"'"'s disease. In such methods, a suitable agent is Aβ peptide or an antibody thereto.
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24 Claims
-
1. A composition comprising an Aβ
- fragment linked to a tetanus toxoid carrier molecule to form a conjugate and an adjuvant, wherein the adjuvant enhances an immune response comprising antibodies to the Aβ
fragment. - View Dependent Claims (2, 3, 4)
- fragment linked to a tetanus toxoid carrier molecule to form a conjugate and an adjuvant, wherein the adjuvant enhances an immune response comprising antibodies to the Aβ
-
5. A method of prophylactically or therapeutically treating a disease characterized by an amyloid deposit of Aβ
- in a patient, comprising;
administering an Aβ
fragment and an adjuvant in a regime effective to induce immune response comprising antibodies to the Aβ
fragment and thereby prophylactically or therapeutically treat the disease in the patient, wherein the Aβ
fragment is linked to a tetanus toxoid carrier molecule to form a conjugate, and the adjuvant enhances the immune response to the Aβ
fragment.- View Dependent Claims (6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
- in a patient, comprising;
Specification