Therapeutics of osteoarthritis and inflammatory joint disease
First Claim
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1. A method for suppressing the incorporation of calcium into chondrocytes or the calcification of cartilage and subchondral bone, comprisingadministering to a patient suffering from a disease that involves the destruction and degeneration of articular cartilage tissue, a therapeutically effective amount of a parathyroid hormone related peptide (PTHrP) or a PTHrP derivative substance comprising amino acids 1-34 of PTHrP.
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Abstract
Drugs for preventing or treating diseases that involve the destruction and degeneration of articular cartilage tissue contain a parathyroid hormone related peptide (PTHrP) or a PTHrP derived substance as an effective ingredient.
23 Citations
6 Claims
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1. A method for suppressing the incorporation of calcium into chondrocytes or the calcification of cartilage and subchondral bone, comprising
administering to a patient suffering from a disease that involves the destruction and degeneration of articular cartilage tissue, a therapeutically effective amount of a parathyroid hormone related peptide (PTHrP) or a PTHrP derivative substance comprising amino acids 1-34 of PTHrP.
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3. A method for suppressing the formation of type X collagen in cartilage, subchondral bone or chondrocytes, comprising
administering to a patient suffering from a disease that involves the destruction and degeneration of articular cartilage tissue, a therapeutically effective amount of a parathyroid hormone related peptide (PTHrP) or a PTHrP derivative substance comprising amino acids 1-34 of PTHrP.
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5. A method for suppressing the alkali phosphatase activity in cartilage, subchondral bone or chondrocytes, comprising
administering to a patient suffering from a disease that involves the destruction and degeneration of articular cartilage tissue, a therapeutically effective amount of a parathyroid hormone related peptide (PTHrP) or a PTHrP derivative substance comprising amino acids 1-34 of PTHrP.
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Current AssigneeMasahiro Iwamoto, Tatsuya Koike, Yukio Kato
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Original AssigneeMasahiro Iwamoto, Tatsuya Koike, Yukio Kato
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InventorsKato, Yukio, Iwamoto, Masahiro, Koike, Tatsuya
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Primary Examiner(s)SAUNDERS, DAVID A
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Application NumberUS08/894,443Time in Patent Office2,576 DaysField of Search530/300, 530/324, 530/350, 530/399, 424/198.1, 514/2, 514/12, 514/825US Class Current514/16.8CPC Class CodesA61K 38/29 Parathyroid hormone, i.e. p...A61P 19/02 for joint disorders, e.g. a...
