Methods for treating diabetes via administration of controlled release metformin

  • US 6,790,459 B1
  • Filed: 11/03/2000
  • Issued: 09/14/2004
  • Est. Priority Date: 11/03/2000
  • Status: Expired due to Term
First Claim
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1. A method for lowering blood glucose levels in human patients needing treatment for non-insulin-dependent diabetes mellitus (NIDDM), comprising orally administering to human patients on a once-a-day basis at least one oral controlled release dosage form comprising an effective dose of metformin or a pharmaceutically acceptable salt thereof and an effective amount of a controlled release carrier to control the release of said metformin or pharmaceutically acceptable salt thereof from said dosage form, wherein following oral administration of a single dose, the dosage form provides a mean time to maximum plasma concentration (Tmax) of metformin at from 5.5 to 7.5 hours after administration following dinner;

  • and the administration of the at least one metformin dosage form provides a mean AUC0-24 of 22590±

    3626 ng·

    hr/ml and a mean Cmax of 2435±

    630 ng/ml on the first day of administration and a mean AUC0-24 of 24136±

    7996 ng·

    hr/ml and a mean Cmax of 2288±

    736 np/ml on the 14th day of administration, for administration of a 2000 mg once-a-day dose of metformin.

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