Intermediate release nicotinic acid compositions for treating hyperlipidemia

  • US 6,818,229 B1
  • Filed: 10/31/1997
  • Issued: 11/16/2004
  • Est. Priority Date: 09/20/1993
  • Status: Expired due to Term
First Claim
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1. An intermediate release nicotinic acid formulation suitable for oral administration once-a-day for treating hyperlipidemia without causing drug-induced hepatotoixicity to a level which woud require use of said intermediate release nicotinic acid formulation to be discontinued, said intermediate release nicotinic acid formulation containing at least about 375 mg of nicotinic acid and having:

  • a nicotinic acid Cmax of about 3 μ

    g/ml;

    a nicotinic acid Tmax in the range of between about 5.6 hours and about 6 bours; and

    an AUC for nictoinic acid of about 6 μ

    ghr/ml.

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