Multi component controlled delivery system for soap bars

• US 6,825,161 B2
• Filed: 11/01/2002
• Issued: 11/30/2004
• Est. Priority Date: 04/26/2002
• Status: Active Grant

• Current Assignee: Salvona LLC
• Original Assignee: Salvona LLC
• Inventors: Shefer, Samuel, Shefer, Adi
• Primary Examiner(s): Hardee, John R.
• Application Number:
  US10/286,143
• Publication Number:
  US 20030207776A1
• Time in Patent Office: 760 Days
• Field of Search: 510/440, 510/441, 510/442, 510/438
• US Class Current: 510/438
• CPC Class Codes: A61K 2800/413 Nanosized, i.e. having sizes below 100 nm
• CPC Class Codes: A61K 2800/56 Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
• CPC Class Codes: A61K 8/0287 the particulate containing a solid-in-solid dispersion
• CPC Class Codes: A61K 8/11 Encapsulated compositions
• CPC Class Codes: A61Q 13/00 Formulations or additives for perfume preparations essential oils or perfumes per se C11B9/00
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: C11D 1/62 Quaternary ammonium compounds
• CPC Class Codes: C11D 17/0039 Coated compositions or coated components in the compositions, (micro)capsules
• CPC Class Codes: C11D 3/505 encapsulated or adsorbed on a carrier, e.g. zeolite or clay
• CPC Class Codes: C11D 9/00 Compositions of detergents based essentially on soap compositions containing resin soap C11D15/04
• CPC Class Codes: C11D 9/26 containing oxygen C11D9/225 takes precedence
• CPC Class Codes: C11D 9/36 containing silicon C11D9/225 takes precedence

Abstract

The present invention relates to an improved controlled delivery system that can be incorporated in soap bars to enhance deposition of active ingredients and sensory markers onto skin. The carrier system also provides controlled release or prolonged release of these actives from the skin over an extended period of time. The controlled delivery system of the present invention comprises substantially free-flowing, powder formed of solid hydrophobic, positively charged, nanospheres of encapsulated active ingredients, that are encapsulated in moisture sensitive microspheres. The high cationic charge density of the nanosphere improves deposition of active ingredients onto skin. The high cationic charge density on the nanosphere surface is created by incorporating a cationic conditioning agent into the solid hydrophobic matrix of the nanospheres, by incorporating a cationic charge “booster” in the moisture sensitive microsphere matrix, or by using a cationic conditioning agent in the nanosphere matrix in conjunction with a cationic charge “booster” in the microsphere matrix. The invention also pertains to soap products comprising the controlled release system of the present invention.

Claims

1. A controlled delivery system for soap comprising:

a plurality of solid positively charged nanospheres, each of said solid nanospheres comprising an effective amount of a first active agent said plurality of nanospheres being encapsulated in a moisture sensitive microsphere, said moisture sensitive microsphere is formed of a moisture sensitive matrix material and a second active agent encapsulated in said moisture sensitive matrix material wherein said first active agent is the same or different than said second active agent, said first active agent and said second active agent is a fragrance and one or more of a vitamin, antimicrobial agent, antifungal agent, anti-inflammatory agent, anti-acne agent, cosmetic soothing active, skin lightening active, sunscreen active, anti-itch active, antioxidant or skin conditioner and wherein said moisture sensitive matrix material releases said second active agent upon contact with moisture.

2. A controlled delivery system for soap comprising:

a plurality of solid positively charged nanospheres, each of said solid nanospheres comprising an effective amount of a first active agent said plurality of nanospheres being encapsulated in a moisture sensitive microsphere, said moisture sensitive microsphere is formed of a moisture sensitive matrix material and a second active agent encapsulated in said moisture sensitive matrix material wherein said system comprises about 1% to about 50% by weight of said hydrophobic matrix material, about 1% to about 50% of said moisture sensitive matrix, from about 0% to about 10% by weight of a cationic charge booster, from about 0.01% to about 10% by weight first and second cationic conditioning agent, and said active agent comprising from about 1% to about 50% by weight fragrance and from 0% to 50% by weight of the nanospheres of an active ingredient and wherein said moisture sensitive matrix material releases said second active agent upon contact with moisture.

3. A controlled delivery system for soap comprising:

a plurality of solid positively charged nanospheres, each of said solid nanospheres comprising an effective amount of a first active agent, said plurality of nanospheres being encapsulated in a moisture sensitive microsphere, said moisture sensitive microsphere is formed of a moisture sensitive matrix material wherein said moisture sensitive matrix material is formed of polyvinyl alcohol in an amount of about 1% to about 80% by weight of the matrix material.

4. A controlled delivery system for soap comprising:

a plurality of solid positively charged nanospheres, each of said solid nanospheres comprising an effective amount of a first active agent, said plurality of nanospheres being encapsulated in a moisture sensitive microsphere, said moisture sensitive microsphere is formed of a moisture sensitive matrix material wherein said nanoparticle comprises a cationic conditioning agent.

5. The system of claim 4 wherein said cationic conditioning agent is selected from the group consisting of cationic quaternary ammonium salts, acyclic quaternary ammonium salts having at least two C₈-C₃₀ alkyl chains, cyclic quaternary ammonium salts of the imidazolinium type, diamide quaternary ammonium salts, biodegradable quaternary ammonium salts, tertiary fatty amines having at least one C₈ to C₃₀ chains, carboxylic acids, esters of polyhydric alcohols, fatty alcohols, ethoxylated fatty alcohols, alkylphenols, ethoxylated alkylphenols, ethoxylated fatty amines, ethoxylated monoglycerides, ethoxylated diglycerides, mineral oil, silicone oil, silicone surfactants and mixtures thereof.

6. The system of claim 4 wherein said cationic conditioning agent is selected from the group consisting of ditallowdimethyl ammonium methylsulfate, di(hydrogenated tallow)dimethyl ammonium methylsulfate, distearyldimethyl ammonium methylsulfate, dicocodimethyl ammonium methylsulfate, di(hydrogenated tallow)dimethyl imidazolinium methylsulfate, 1-ethylene-bis(2-tallow 1-methyl) imidazolinium methylsulfate, methyl-bis(hydrogenated tallow amidoethyl)-2-hydroxyethyl ammonium methyl sulfate, methyl bis(tallowamidoethyl)-2-hydroxypropyl ammonium methylsulfate, N,N-di (tallowoyl-oxy-ethyl)-N,N,-dimethyl ammonium methyl sulfate, N,N-di (tallowoyl-oxy-propyl)-N,N-dimethyl ammonium methyl sulfate, tallow-di-methylamine, cyclic amines, 1-(hydrogenated tallow)amidoethyl-2-(hydrogenated tallow)imidazoline and mixtures thereof.

7. The system of claim 4 wherein said cationic conditioning agent is selected from the group consisting of:

behenyltrimethylammonium chloride;

ditallowdimethylammonium methylsulfate;

ditallowdimethylammonium chloride;

methyl(1) stearylamidoethyl (2) stearylimidazolinium methosulfate;

methyl(1)stearylamidoethyl(2)stearylimidazolinium chloride;

N,N-di(tallowyl-oxy-ethyl)-N,N-dimethyl ammonium chloride;

N,N-di(canolyl-oxy-ethyl)-N,N-dimethyl ammonium chloride;

N,N-di(tallowyl-oxy-ethyl)-N-methyl, N-(2-hydroxyethyl) ammonium chloride;

N,N-di(canolyl-oxy-ethyl)-N-methyl, N-(2-hydroxyethyl) ammonium chloride;

N,N-di(2-tallowyloxy-2-oxo-ethyl)-N,N-dimethyl ammonium chloride;

N,N-di(2-canolyloxy-2-oxo-ethyl)-N,N-dimethyl ammonium chloride;

N,N-di(2-tallowyloxyethylcarbonyloxyethyl)-N,N-dimethyl ammonium chloride;

N,N-di(2-canolyloxyethylcarbonyloxyethyl)-N,N-dimethyl ammonium chloride;

N-(2-tallowoyloxy-2-ethyl)-N-(2-tallowyloxy-2-oxo-ethyl)-N,N-dimethyl ammonium chloride;

N-(2-canolyloxy-2-ethyl)-N-(2-canolyloxy-2-oxo-ethyl)-N,N-dimethyl ammonium chloride;

N,N,N-tri(tallowyl-oxy-ethyl)-N-methyl ammonium chloride;

N,N,N-tricanolyl-oxy-ethyl)-N-methyl ammonium chloride;

N-(2-tallowyloxy-2-oxoethyl)-N-(tallowyl)-N,N-dimethyl ammonium chloride;

N-(2-canolyloxy-2-oxoethyl)-N-(canolyl)-N,N-dimethyl ammonium chloride;

1,2-ditallowyloxy-3-N,N,N-trimethylammoniopropane chloride;

1,2-dicanolyloxy-3-N,N,N-trimethylammoniopropane chloride;

methyl-1-tallowamidoethyl-2-tallowimidazolinium methylsulfate;

monotallowtrimethylammonium chloride;

mono(hydrogenated tallow)trimethylammonium chloride;

palmityltrimethyl ammonium chloride;

soyatrimethylammonium chloride;

dimethylstearylbenzyl ammonium chloride and mixtures thereof.

8. A controlled delivery system for soap comprising:

a plurality of solid positively charged nanospheres, each of said solid nanospheres comprising an effective amount of a first active agent, said plurality of nanospheres being encapsulated in a moisture sensitive microsphere, said moisture sensitive microsphere is formed of a moisture sensitive matrix material wherein said microparticle comprises a cationic charge booster.

9. The system of claim 8 wherein said cationic charge booster is selected from the group consisting of a quaternary ammonium compound, polyvinyl amine, polyalkyleneimine, and poly-quaternary ammonium compound.

10. The system of claim 8 wherein said cationic charge boosters comprises polyethyleneimine having an average molecular weight of 1,800.

11. A controlled delivery system for soap comprising:

a plurality of solid positively charged nanospheres, each of said solid nanospheres comprising an effective amount of a first active agent, said plurality of nanospheres being encapsulated in a moisture sensitive microsphere, said moisture sensitive microsphere is formed of a moisture sensitive matrix material wherein said nanoparticle comprises a cationic conditioning agent and said microparticle comprises cationic charge booster.

12. The system of claim 11 wherein said cationic conditioning agent is selected from the group consisting of cationic quaternary ammonium salts, acyclic quaternary ammonium salts having at least two C₈-C₃₀ alkyl chains, cyclic quaternary ammonium salts of the imidazolinium type, diamide quaternary ammonium salts, biodegradable quaternary ammonium salts, tertiary fatty amines having at least one C₈ to C₃₀ chains, carboxylic acids, esters of polyhydric alcohols, fatty alcohols, ethoxylated fatty alcohols, alkylphenols, ethoxylated alkylphenols, ethoxylated fatty amines, ethoxylated monoglycerides, ethoxylated diglycerides, mineral oil, silicone oil, silicone surfactants and mixtures thereof.

13. The system of claim 11 wherein said cationic charge booster is selected from the group consisting of a quaternary ammonium compound, polyvinyl amine, polyalkyleneimine, and poly-quaternary ammonium compound.

14. An article of manufacture comprising a controlled delivery system for soap comprising a plurality of solid positively charged nanospheres, each of said solid nanospheres comprising an effective amount of a first active agent said plurality of nanospheres being encapsulated in a moisture sensitive microsphere, said moisture sensitive microsphere is formed of a moisture sensitive matrix material wherein said article is a soap bar.

15. A method for forming a controlled delivery system for soap comprising a plurality of solid positively charged nanospheres, each of said solid nanospheres comprising an effective amount of a first active agent said plurality of nanospheres being encapsulated in a moisture sensitive microsphere, said moisture sensitive microsphere is formed of a moisture sensitive matrix material, wherein the method comprises the steps of:

heating a hydrophobic material to a temperature above the melting point to form a melt;

dissolving or dispersing a cationic conditioning agent into the melt;

dissolving or dispersing said first active agent into the melt;

dissolving or dispersing a second active agent and fragrance, a cationic charge booster, and a water sensitive materials;

mixing the hot melt with the aqueous phase to form an dispersion; and

high shear homogenization of the dispersion at a temperature above the melting temperature until a homogeneous fine dispersion is obtained,

cooling the dispersion to ambient temperature; and

spray drying the emulsified mixed suspension to form a dry powder composition.

16. A method for forming a controlled delivery system for soap comprising a plurality of solid positively charged nanospheres, each of said solid nanospheres comprising an effective amount of a first active agent said plurality of nanospheres being encapsulated in a moisture sensitive microsphere, said moisture sensitive microsphere is formed of a moisture sensitive matrix material and a second active agent encapsulated in said moisture sensitive matrix material, wherein said moisture sensitive matrix material releases said second active agent upon contact with moisture, wherein the method comprises the steps of:

heating a hydrophobic material to a temperature above the melting point to form a melt;

dissolving or dispersing a cationic conditioning agent into the melt;

dissolving or dispersing said first active agent into the melt;

dissolving or dispersing said second active agent, a cationic charge booster, and a water sensitive material in the aqueous phase and heating it to above the melting temperature of the hydrophobic material;

mixing the hot melt with the aqueous phase to form an dispersion;

high shear homogenization of the dispersion at a temperature above the melting temperature until a homogeneous fine dispersion is obtained;

cooling the dispersion to ambient temperature; and

spray drying the emulsified mixed suspension to form a dry powder composition.