Implantable refillable and ported controlled release drug delivery device
First Claim
1. An implantable, refillable, rate controlled drug delivery device, comprising:
- a base structure having at least a first opening and a second opening, the base structure defining a chamber;
a septum covering the first opening and configured to substantially prevent leakage from the first opening to an exterior of the device;
a drug delivery tube comprising a proximal end and a distal end, wherein the proximal end of the tube communicates with the chamber through the second opening, and at least one rate-limiting permeable membrane disposed at least partially within said chamber and across a passage between the base structure and said drug delivery tube proximal end, which membrane passively regulates drug delivery.
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0 Petitions
Accused Products
Abstract
An implantable, refillable, rate controlled drug delivery device is disclosed that includes a base structure having at least a first opening and a second opening, the base structure defining a chamber, a septum covering the first opening and configured to substantially prevent leakage from the first opening to an exterior of the device, a drug delivery tube comprising a first and second distal end, wherein the first distal end of the tube communicates with the chamber through the second opening, and at least one rate-limiting permeable membrane disposed across a passage between the base structure and the second distal end of the drug delivery tube, which membrane passively regulates drug delivery. The drug delivery device is used to provide controlled drug delivery to an internal portion of the body and is advantageously leak-proof and does not rely on a pressure differential to drive the drug from the device.
155 Citations
20 Claims
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1. An implantable, refillable, rate controlled drug delivery device, comprising:
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a base structure having at least a first opening and a second opening, the base structure defining a chamber;
a septum covering the first opening and configured to substantially prevent leakage from the first opening to an exterior of the device;
a drug delivery tube comprising a proximal end and a distal end, wherein the proximal end of the tube communicates with the chamber through the second opening, and at least one rate-limiting permeable membrane disposed at least partially within said chamber and across a passage between the base structure and said drug delivery tube proximal end, which membrane passively regulates drug delivery. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. The implantable, refillable, rate controlled drug delivery device comprising:
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a base structure having at least a first opening and a second opening, the base structure defining a chamber;
a septum covering the first opening and configured to substantially prevent leakage from the first opening to an exterior of the device;
a drug delivery tube comprising a proximal end and a distal end, wherein the proximal end of the tube communicates with the chamber through the second opening;
a rate-limiting permeable membrane disposed at least partially within said chamber and across a passage between the base structure and said drug delivery tube proximal end, which membrane passively regulates drug delivery;
a filter housing provided within the chamber adjacent the second opening; and
a filter element provided between the rate-limiting permeable membrane and the filter housing. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. An implantable, refillable, rate controlled drug delivery device comprising:
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a base structure having at least a first opening and a second opening, the base structure defining a chamber;
a septum covering the first opening and configured to substantially prevent leakage from the first opening to an exterior of the device;
a drug delivery tube comprising a proximal end and a distal end, wherein the proximal end of the tube communicates with the chamber through the second opening;
at least one rate-limiting permeable membrane disposed across a passage between the base structure and the distal end of the drug delivery tube, which membrane passively regulates drug delivery;
a filter housing provided within the chamber adjacent the second opening;
a filter element provided between the rate-limiting permeable membranes and the filter housing, and a depressed region at least partially circumscribing the second opening, wherein an upper portion of the filter housing comprises a needle stop, wherein the upper portion of the filter housing comprising a needle stop is disposed over the second opening, wherein the upper portion of the filter housing comprising a needle stop comprises a plurality of perforations, and wherein the rate-limiting permeable membrane is positioned at least partially within the depressed region.
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Specification