Method for determining the concentration of glucose in a body fluid with glucose-containing perfusate

  • US 6,852,500 B1
  • Filed: 07/20/2000
  • Issued: 02/08/2005
  • Est. Priority Date: 07/28/1999
  • Status: Expired due to Fees
  • ×
    • Pin Icon | RPX Insight
    • Pin
First Claim
Patent Images

1. A method for determining a glucose concentration in a body fluid with glucose-containing perfusate, the method comprising the steps of:

  • providing a microdialysis probe, a measuring cell having a sensor, and a control device, inserting the microdialysis probe into the body fluid, passing the perfusate having a pre-determined starting content of glucose through the microdialysis probe to obtain a dialysate, transporting the dialysate to the measuring cell, obtaining with the sensor measurement signals from the dialysate, the dialysate serving as an electrolyte and being used to continuously register a measuring current, which correlates with a glucose content of the dialysate in the measuring cell, determining from the measurement signals a base line value corresponding to a starting concentration of glucose in the perfusate and the existence of a peak value, the peak value being present when there are differences in concentration between the starting concentration of glucose in the perfusate and the concentration of glucose in the body fluid, adjusting the starting content of glucose in the perfusate to a glucose content of the body fluid with the control device in accordance with a command variable corresponding with the glucose concentration of the body fluid and being derived from the measurement signals of the measuring cell, wherein the glucose concentration in the body fluid is determined by either using a momentary content of glucose in the perfusate as a measure for the glucose content of the body fluid when a deviation between the peak value and the base line value is negligible or by determining the glucose content of the body fluid directly from the obtained measurement signals.

View all claims
  • 1 Assignment
    ×
    ×

    Thank you for your feedback

    ×
    ×