Stabilized insulin formulations

  • US 6,852,694 B2
  • Filed: 02/21/2002
  • Issued: 02/08/2005
  • Est. Priority Date: 02/21/2001
  • Status: Active Grant
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First Claim
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1. A method of making an insulin heterodimer composition, the method comprising:

  • (a) selecting a first insulin species comprising human insulin and a second insulin species comprising a human insulin polypeptide having an amino acid substitution at position 28 in the beta chain;

    (b) adding the first insulin species and the second insulin species together in a aqueous solution comprising a pharmaceutically acceptable carrier;

    (c) allowing the first insulin species and the second insulin species to associate in the solution so that the insulin heterodimer composition is made;

    wherein the first insulin species and the second insulin species are selected so that the heterodimer formed by the first insulin species and the second insulin species is more stable than a homodimer formed by the second insulin species.

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