Device and method for determining analyte levels

  • US 6,862,465 B2
  • Filed: 07/27/2001
  • Issued: 03/01/2005
  • Est. Priority Date: 03/04/1997
  • Status: Expired due to Term
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1. An implantable device for measuring an analyte in a biological fluid, comprising;

  • a) a housing comprising an electronic circuit; and

    b) a sensor operably connected to said electronic circuit of said housing, said sensor comprising i) a member for determining the amount of glucose in a biological sample ii) a bioprotective membrane said bioprotective membrane positioned more distal to said housing than said glucose determining member and substantially impermeable to macrophages, iii) an angiogenic layer, said angiogenic layer positioned more distal to said housing than said bioprotective membrane, and iv) an interference layer between said bioprotective membrane and said glucose determining member, wherein said interference layer further comprises a metal film on the side of said layer distal to said sensor.

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