Methods of monitoring glucose levels in a subject and uses thereof

  • US 6,862,466 B2
  • Filed: 04/23/2003
  • Issued: 03/01/2005
  • Est. Priority Date: 08/28/2000
  • Status: Active Grant
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First Claim
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1. A method for achieving a weight management goal in a subject, said method comprisingdetermining a reference range of glucose amounts or concentrations that correspond to achieving the weight management goal in the subject, said range of glucose amounts or concentrations comprising a high threshold glucose value and a low threshold glucose value;

  • monitoring glucose amount or concentration in the subject by a glucose monitoring method comprising transdermally extracting a sample comprising glucose from the subject using a sampling system that is in operative contact with a skin or mucosal surface of said subject, wherein the extracting is carried out using an iontophoretic system comprising first and second iontophoretic electrodes;

    contacting the sample with a sensor element in the presence of glucose oxidase that reacts with glucose to produce hydrogen peroxide;

    detecting the hydrogen peroxide with the sensor element that reacts electrochemically with the hydrogen peroxide to produce a detectable signal, wherein said detectable signal is specifically related to glucose amount or concentration in the subject;

    measuring the detectable signal;

    correlating the detectable signal to an amount or concentration of glucose in the subject; and

    repeating said glucose monitoring method to obtain a series of glucose amounts or concentrations, in the subject, at selected time intervals;

    maintaining a record of at least caloric intake; and

    comparing said series of glucose amounts or concentrations, said record, and said reference range to evaluate compliance with the reference range of glucose amounts or concentrations to achieve the weight management goal of the subject.

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