Method for treating obsessive-compulsive disorder with electrical stimulation of the brain internal capsule
First Claim
1. A method for modulating brain internal capsule tissue to treat obsessive-compulsive disorder, comprising:
- placing at least a first lead having at least a first proximal electrode and at least a first distal electrode in an internal capsule anterior portion;
connecting the first lead to a neurological stimulator;
configuring the first proximal electrode and the first distal electrode in a manner to deliver a stimulation signal generally parallel to axons in the internal capsule;
delivering the stimulation signal to the first proximal electrode and the first distal electrode; and
, modulating neural activity in the internal capsule anterior portion.
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Accused Products
Abstract
A method for treating a patient with an obsession, a compulsion, an anxiety or a depression disorder, comprising applying chronic electrical stimulation to at least a portion of the patient'"'"'s anterior limb of the internal capsule under conditions effective to provide the patient with at least a partial relief from obsession and/or compulsion and/or anxiety and/or depression, by means of an electrical signal generator and at least an implantable electrode having a proximal end coupled to the said signal generator and a stimulation end capable of applying said chronic electrical stimulation, wherein the distance between the two outer contacts of the electrode corresponds to the depth of the internal capsule.
A method is disclosed for treating a patient with an obsession, a compulsion, an anxiety or a depression disorder. The method comprises applying electrical stimulation to at least a portion of the patient'"'"'s anterior limb of the internal capsule or its surrounding structures including but not limited to the head of the caudate nucleus, putamen and nucleus accumbens. The electrical stimulation is applied by means of an electrical signal generator and at least an implantable electrode having a proximal end coupled to the signal generator and a stimulation end capable of applying electrical stimulation to the tissue.
99 Citations
34 Claims
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1. A method for modulating brain internal capsule tissue to treat obsessive-compulsive disorder, comprising:
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placing at least a first lead having at least a first proximal electrode and at least a first distal electrode in an internal capsule anterior portion;
connecting the first lead to a neurological stimulator;
configuring the first proximal electrode and the first distal electrode in a manner to deliver a stimulation signal generally parallel to axons in the internal capsule;
delivering the stimulation signal to the first proximal electrode and the first distal electrode; and
,modulating neural activity in the internal capsule anterior portion. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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- 13. A method for treating a patient with an obsession, a compulsion, an anxiety or a depression disorder, comprising applying chronic electrical stimulation to at least a portion of an anterior limb of an internal capsule of the brain of the patient under conditions effective to provide the patient with at least a partial relief from at least one of obsession, compulsion, anxiety, and depression by means of an electrical signal generator and at least an implantable electrode having a proximal end coupled to the said signal generator and a stimulation end capable of applying said chronic electric stimulation, the said conditions being such that electrical stimulation results in at least one of a significant increase in neuronal activity in cortical and subcortical structures as measured by functional magnetic resonance imaging and a change in metabolism as measured by Positron Emission Tomography (PET).
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21. A method for treating a patient with an obsession, a compulsion, an anxiety or a depression disorder, comprising applying chronic electrical stimulation bilaterally to at least a portion of an anterior limb of each of the first and second internal capsules of the brain of the patient under conditions effective to provide the patient with at least a partial relief from at least one of obsession, compulsion, anxiety, and depression by means of an electrical signal generator and at least an implantable electrode having a proximal end coupled to the said signal generator and a stimulation end capable of applying said chronic electrical stimulation, the said conditions including a voltage in the range from about 0.5 volt to about 12 volts, a pulse width in the range from about 60 μ
- s to about 450 μ
s and a frequency in the range from about 50 Hz to about 200 Hz. - View Dependent Claims (22, 23, 24)
- s to about 450 μ
- 25. A method for treating a patient with an obsession, a compulsion, an anxiety or a depression disorder, comprising applying chronic electrical stimulation to at least a portion of an anterior limb of an internal capsule of the brain of the patient under conditions effective to provide the patient with at least a partial relief from at least one of obsession, compulsion, anxiety, and depression by means of an electrical signal generator and at least an implantable electrode having a proximal end coupled to the said signal generator and a stimulation end capable of applying said chronic electrical stimulation, wherein the distance between the two outer contacts of the electrode corresponds to the depth of the internal capsule.
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28. A device for electrically stimulating a human brain tissue, comprising:
- at least an implantable electrode having a proximal end for coupling to a signal generator and a stimulation end for applying electrical stimulation to at least a portion of an anterior limb of an internal capsule of the brain of a human, wherein the distance between the two outer contacts of the implantable electrode corresponds to the depth of the internal capsule.
- View Dependent Claims (29, 30, 31, 32)
- 33. A method for treating a patient with an obsession, a compulsion, an anxiety or a depression disorder comprising applying electrical stimulation bilaterally to at least a portion of an anterior limb of each of first and second internal capsules of the brain of the patient by means of an electrical signal generator that provides said electrical stimulation and at least two implantable leads, each of the implantable leads having a distal end that is capable of applying said electrical stimulation and implanted proximate to a respective one of the anterior limbs of the internal capsules.
Specification