Treatment of bioprosthetic tissues to mitigate post implantation calcification

  • US 6,878,168 B2
  • Filed: 01/03/2002
  • Issued: 04/12/2005
  • Est. Priority Date: 01/03/2002
  • Status: Active Grant
First Claim
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1. A method for mitigating post-implantation calcification of a bioprosthetic material, said method comprising the steps of:

  • (a) heating a glutaraldehyde solution having a pH of between 7.2-7.8 to a first temperature above 20°

    C. for a first period of time of at least one hour until the pH of the glutaraldehyde solution has been reduced to between 5-7; and

    (c) contacting a quantity of biological tissue that contains connective tissue protein with the pH-reduced glutaraldehyde solution for a second period of time of at least one hour.

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