Measurement of sleep apnea duration and evaluation of response therapies using duration metrics

• US 6,881,192 B1
• Filed: 06/12/2002
• Issued: 04/19/2005
• Est. Priority Date: 06/12/2002
• Status: Expired due to Fees

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Park, Euljoon
• Primary Examiner(s): Nasser, Robert L.
• Assistant Examiner(s): MALLARI, PATRICIA C
• Application Number:
  US10/170,384
• Time in Patent Office: 1,042 Days
• Field of Search: 600/300, 600/301, 600/484, 600508-525, 600529-543, 600/595, 607 1- 6, 607 17- 20, 607/119, 607/42
• US Class Current: 600/529
• CPC Class Codes: A61B 2562/0219 Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
• CPC Class Codes: A61B 5/0535 Impedance plethysmography for measuring blood flow A61B5/0295
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/4818 Sleep apnoea
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters

Abstract

An implantable cardiac device is programmed to detect an episode of sleep apnea, measure the duration of the episode, and store this information in memory. When multiple episodes are recorded, the device computes statistics on the apnea durations, such as average apnea duration and total apnea duration for a preselected time period (e.g., 8-hour rest period, 24-hour day, etc.). The implantable cardiac device may further be used to administer pacing therapy in response to detecting sleep apnea. Under the control of a physician, the implantable device may be programmed to administer different types of responsive therapies to evaluate whether certain therapies are more effective at treating apnea than others. For instance, a pacing therapy that results in lowering the average apnea duration or total apnea duration may be preferred over other pacing therapies that do not achieve such results.

Claims

1. An implantable cardiac device comprising:

sensing circuitry to sense whether a patient is at rest;

a sleep apnea detector to detect when a patient, who is at rest, is experiencing an episode of sleep apnea and to measure a duration of the episode of sleep apnea;

a therapy module to prescribe a pacing therapy for treating sleep apnea from among multiple different pacing therapies;

a pulse generator to generate pacing pulses according to the prescribed pacing therapy for an evaluation timeframe; and

the sleep apnea detector measuring durations of episodes experienced during the evaluation timeframe of the prescribed pacing therapy.

2. An implantable cardiac device as recited in claim 1, wherein the sensing circuitry comprises an activity sensor to sense a patient'"'"'s activity to determine whether the patient is at rest.

3. An implantable cardiac device as recited in claim 1, wherein the sensing circuitry comprises a position sensor to sense a patient'"'"'s position as a way to determine whether the patient is at rest.

4. An implantable cardiac device as recited in claim 1, wherein the sensing circuitry comprises an accelerometer that is used to determine whether the patient is at rest.

5. An implantable cardiac device as recited in claim 1, wherein the sensing circuitry is configured to sense a respiration-related signal and the sleep apnea detector detects the episode of sleep apnea based upon the respiration-related signal.

6. An implantable cardiac device as recited in claim 5, wherein the sensing circuitry comprises an impedance sensor to detect the respiration-related signal.

7. An implantable cardiac device as recited in claim 5, wherein the respiration-related signal is selected from a group of signals comprising a signal indicative of tidal volume, a signal indicative of respiration rate, and a signal indicative of minute ventilation, and O₂ saturation.

8. An implantable cardiac device as recited in claim 5, wherein the sleep apnea detector is configured to detect the episode of sleep apnea by determining when the respiration-related signal exceeds a first threshold indicative of hyperventilation and then falls below a lower second threshold for a predetermined time period.

9. An implantable cardiac device as recited in claim 1, wherein the sensing circuitry is configured to sense an oxygen-related signal and the sleep apnea detector detects the episode of sleep apnea based upon the oxygen-related signal.

10. An implantable cardiac device as recited in claim 1, further comprising a memory to store apnea data pertaining to the episode of sleep apnea and the duration of the episode.

11. An implantable cardiac device as recited in claim 1, further comprising a statistical module to derive statistics on the duration of the sleep apnea episode.

12. An implantable cardiac device as recited in claim 1, further comprising a pulse generator to generate pacing pulses applied in response to the sleep apnea detector detecting the episode of sleep apnea.

13. A method implemented by an implantable cardiac device, comprising:

detecting an episode of sleep apnea;

determining a duration of the sleep apnea episode;

stimulating a heart in response to at least selected episodes of sleep apnea;

administering multiple different pacing therapies to treat the sleep apnea; and

evaluating the pacing therapies based on how the pacing therapies affect the duration of the sleep apnea episodes.

14. An implantable cardiac device comprising:

a rest-indicating sensor to sense whether a patient is at rest;

a respiration sensor to sense respiration;

a processor to confirm that a patient is at rest based on data from the rest-indicating sensor and while the patient is resting, to detect an episode of sleep apnea based on changes in the respiration, the processor being further configured to measure a duration of the episode of sleep apnea; and

a memory to store apnea data pertaining to the episode of sleep apnea and the duration of the episode;

wherein the processor is configured to detect the episode of sleep apnea in an event that the respiration exceeds a first threshold indicative of hyperventilation and then falls below a lower second threshold for a predetermined time period and wherein the processor measures the duration of the episode of sleep apnea as a time period starting when the respiration falls below the second threshold until and ending when the respiration once again exceeds the second threshold.

15. An implantable cardiac device as recited in claim 14, wherein the rest-indicating sensor comprises at least one of an activity sensor, a position sensor, or an accelerometer.

16. An implantable cardiac device as recited in claim 14, wherein the respiration sensor comprises an impedance sensor configured as a minute ventilation sensor.

17. A method comprising:

administering multiple different pacing therapies to treat sleep apnea using an implantable cardiac device, such that each pacing therapy is administered to treat all episodes of sleep apnea that occur within a corresponding evaluation timeframe;

compiling duration metrics pertaining to duration of the sleep apnea episodes; and

analyzing the duration metrics to evaluate how effective the different pacing therapies are at treating the sleep apnea.

18. A method as recited in claim 17, wherein the compiling comprises:

measuring duration of each sleep apnea episode; and

computing at least one of total apnea duration and average apnea duration of all sleep apnea episodes that occur within the corresponding evaluation timeframe.

19. A method as recited in claim 17, further comprising transmitting the duration metrics to an external device and performing the analyzing at the external device.

20. An implantable cardiac device comprising:

a rest-indicating sensor to sense whether a patient is at rest;

a respiration sensor to sense respiration;

a processor to confirm that a patient is at rest based on data from the rest-indicating sensor and while the patient is testing, to detect an episode of sleep apnea based on changes in the respiration, the processor being further configured to measure a duration of the episode of sleep apnea; and

a memory to store apnea data pertaining to the episode of sleep apnea and the duration of the episode;

wherein the processor stores apnea data for multiple episodes and computes statistics on the apnea data and wherein the processor derives an average duration and a total duration of the multiple episodes.

21. An implantable cardiac device as recited in claim 20, further comprising a pulse generator to generate pacing pulses applied in response to the sleep apnea.

22. An implantable and programmable cardiac device having a memory and a processor, the cardiac device being programmed to perform tasks comprising:

sensing an oxygen-related parameter;

detecting an episode of sleep apnea in an event that the oxygen-related parameter falls below a threshold for a predetermined time period suggestive of apnea; and

measuring a duration of the episode of steep apnea taken from a start time when the oxygen-related parameter first falls below the threshold until an end time when the oxygen-related parameter subsequently rises above the threshold.

23. An implantable and programmable cardiac device as recited in claim 22, further programmed to perform tasks comprising:

storing durations measured for multiple apnea episodes; and

computing at least one of an average duration and a total duration from the multiple episodes.

24. An implantable and programmable cardiac device as recited in claim 22, further programmed to perform tasks comprising applying an increased rate of pacing pulses in response to detecting onset of sleep apnea.

25. An implantable cardiac device comprising:

a rest-indicating sensor to sense whether a patient is at rest;

an oxygen sensor to sense O₂ saturation;

a processor to confirm that a patient is at rest based on data from the rest-indicating sensor and while the patient is resting, to detect an episode of sleep apnea based on changes in the O₂ saturation, the processor being further configured to measure a duration of the episode of sleep apnea; and

a memory to store apnea data pertaining to the episode of sleep apnea and the duration of the episode;

wherein the processor is configured to detest the episode of sleep apnea in an event that the O₂ saturation falls below a threshold for a predetermined time period and wherein the processor measures the duration of the episode of sleep apnea as a time period starting when the O₂ saturation falls below the threshold until and ending when the O₂ saturation once again exceeds the threshold.

26. An implantable cardiac device as recited in claim 25, wherein the processor stores apnea data for multiple episodes and computes statistics on the apnea data.

27. An implantable cardiac device comprising:

a rest-indicating sensor to sense whether a patient is at rest;

an oxygen sensor to sense O₂ saturation;

a processor to confirm that a patient is at rest based on data from the rest-indicating sensor and while the patient is resting, to detect an episode of sleep apnea based on changes in the O₂ saturation, the processor being further configured to measure a duration of the episode of sleep apnea;

a memory to store apnea data pertaining to the episode of sleep apnea and the duration of the episode

a therapy module to prescribe a pacing therapy for treating sleep apnea from among multiple different pacing therapies;

a pulse generator to generate pacing pulses according to the prescribed pacing therapy for an evaluation timeframe; and

the sleep apnea detector measuring durations of episodes experienced during the evaluation timeframe of the prescribed pacing therapy.

28. A method implemented by an implantable cardiac device, comprising:

detecting an episode of sleep apnea;

determining a duration of the sleep apnea episode; and

stimulating a heart in response to at least selected episodes of sleep apnea;

wherein the detecting comprises determining when a respiration signal exceeds a first threshold indicative of hyperventilation and then falls below a lower second threshold for a predetermined period of time and wherein the determining comprises measuring the duration from a start time when the respiration signal falls below the second threshold until an end time when the respiration signal rises above the second threshold.

29. A method as recited in claim 28, wherein the detecting comprises monitoring a respiration signal for a pattern of hyperventilation followed by minimal respiration activity.

30. A method as recited in claim 28, wherein the detecting comprises monitoring an oxygen-related parameter and determining when the oxygen-related parameter falls below a threshold of minimal oxygen content for a predetermined time period.

31. A method as recited in claim 28, further comprising:

storing durations of multiple episodes of sleep apnea; and

computing one or more statistics on the durations of the multiple episodes.

32. A method as recited in claim 28, further comprising administering pacing therapy in response to detecting the episode of sleep apnea.

33. A method comprising:

determining that a patient is at rest;

monitoring a respiration signal;

detecting an episode of sleep apnea in an event that, while the patient is at rest, the respiration signal exceeds a first threshold associated with hyperventilation and then falls below a lower second threshold for a predetermined time period suggestive of apnea;

measuring a duration of the episode of sleep apnea; and

storing the duration of the sleep apnea;

wherein measuring comprises timing the duration from a start time when the respiration signal first falls below the second threshold until an end time when the respiration signal subsequently rises above the second threshold.

34. A method as recited in claim 33, wherein the determining comprises monitoring the patient'"'"'s position to determine if the patient is in a supine position.

35. A method as recited in claim 33, wherein the determining comprises monitoring patient activity.

36. A method as recited in claim 33, further comprising:

storing durations of multiple episodes of sleep apnea; and

computing one or more statistics on the durations of the multiple episodes.

37. A method as recited in claim 33, further comprising administering pacing therapy in response to the onset of sleep apnea.

38. An implantable and programmable cardiac device having a memory and a processor, the cardiac device being programmed to perform tasks comprising:

detecting when a patient is experiencing an episode of sleep apnea;

determining a duration of the sleep apnea episode; and

stimulating a heart in response to at least selected episodes of sleep apnea;

storing durations measured for multiple apnea episodes; and

computing at least one of an average duration and a total duration from the multiple episodes.

39. An implantable and programmable cardiac device as recited in claim 38, further programmed to perform tasks comprising applying an increased rate of pacing in response to detecting onset of sleep apnea.

40. An implantable and programmable cardiac device having a memory and a processor, the cardiac device being programmed to perform tasks comprising:

sensing a respiration signal;

detecting an episode of sleep apnea in an event that the respiration signal exceeds a first threshold associated with hyperventilation followed by falling below a lower second threshold for a predetermined time period suggestive of apnea; and

measuring a duration of the episode of sleep apnea taken from a start time when the respiration signal first falls below the second threshold until an end time when the respiration signal subsequently rises above the second threshold.

41. An implantable and programmable cardiac device as recited in claim 40, further programmed to perform tasks comprising:

storing durations measured for multiple apnea episodes; and

computing at least one of an average duration and a total duration from the multiple episodes.

42. An implantable and programmable cardiac device as recited in claim 40, further programmed to perform tasks comprising applying an increased rate of pacing pulses in response to detecting onset of sleep apnea.

43. An implantable cardiac device comprising:

a rest-indicating sensor to sense whether a patient is at rest;

a respiration sensor to sense respiration;

a processor to confirm that a patient is at rest based on data from the rest-indicating sensor and while the patient is resting, to detect an episode of sleep apnea based on changes in the respiration, the processor being further configured to measure a duration of the episode of sleep apnea;

a memory to store apnea data pertaining to the episode of sleep apnea and the duration of the episode;

a therapy module to prescribe a pacing therapy for treating sleep apnea from among multiple different pacing therapies;

a pulse generator to generate pacing pulses according to the prescribed pacing therapy for an evaluation timeframe; and

the sleep apnea detector measuring durations of episodes experienced during the evaluation timeframe of the prescribed pacing therapy.

44. A system comprising:

an implantable cardiac device configured to detect episodes of sleep apnea and to administer different pacing therapies for treating the sleep apnea, the implantable cardiac device being further configured to collect duration metrics pertaining to durations of sleep apnea episodes measured for the different pacing therapies and to export the duration metrics to an external computing device; and

a computing system to analyze the duration metrics collected by the implantable cardiac device.

45. A system as recited in claim 44, wherein the implantable cardiac device comprises:

a sensor to sense a respiration signal; and

a processor programmed to detect an episode of sleep apnea in an event that the respiration signal exceeds a first threshold associated with hyperventilation followed by falling below a lower second threshold for a predetermined time period suggestive of apnea, the processor measuring the duration between a start time when the respiration signal first falls below the second threshold and an end time when the respiration signal subsequently rises above the second threshold.

46. A system as recited in claim 44, wherein the implantable cardiac device comprises:

an oxygen sensor to sense an oxygen-related parameter; and

a processor programmed to detect an episode of sleep apnea in an event that the oxygen-related parameter falls below a threshold for a predetermined time period suggestive of apnea, the processor measuring the duration between a start time when the oxygen-related parameter first falls below the threshold and an end time when the oxygen-related parameter subsequently rises above the threshold.

47. A system as recited in claim 44, wherein the implantable cardiac device computes statistics on the duration metrics collected for each pacing therapy and stores the statistics for export to the external computing device.

48. A system as recited in claim 44, wherein the implantable cardiac device administers each pacing therapy for a predefined evaluation timeframe and the computer system analyzes the duration metrics collected for the different pacing therapies to identify one or more therapies that are effective at treating sleep apnea.