Multilayered analytical device

• US 6,881,378 B1
• Filed: 03/17/2000
• Issued: 04/19/2005
• Est. Priority Date: 03/19/1999
• Status: Active Grant

• Current Assignee: Roche Diagnostics GmbH (Roche Holding AG)
• Original Assignee: Roche Diagnostics GmbH (Roche Holding AG)
• Inventors: Zimmer, Volker, Braun, Hans-Peter
• Primary Examiner(s): Alexander, Lyle A.
• Time in patent office: 1859 Days
• Field of Search: 422/56, 422/58, 422/61, 436/164, 436/166, 436168-170
• US Class Current: 422/419
• CPC Class Codes: G01N 33/525 Multi-layer analytical elements
• CPC Class Codes: G01N 33/54393 Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding

Abstract

The invention concerns an analytical device containing at least two components in which at least two of the components are joined together with the aid of an adhesive, which is characterized in that the adhesive contains an adsorptive material. The invention additionally concerns the use of adhesives which contain adsorptive material to manufacture analytical devices.

Claims

1. An analytical device adapted for use with sample liquids, said analytical device comprising:

a carrier layer;

at least two functional layers comprising a detection layer, a separation layer constructed of a membrane or fleece, a transport layer, a layer for the uptake of excess sample, or a spreading layer, and

an adhesive comprising a porous solid adsorptive material positioned between at least two of said functional layers,

wherein at least two of said functional layers are joined together with the aid of the adhesive and

wherein said adhesive is formed to join together at least two of said functional layers during contact of the liquid sample with the functional layer.

2. The analytical device of claim 1 wherein the adsorptive material comprises a porous solid.

3. The analytical device of claim 2 wherein the solid is not soluble in the adhesive.

4. The analytical device of claim 2 wherein the solid comprises at least one of an activated charcoal, a carbon black, an aluminium oxide, a silica gel or a zeolite.

5. The analytical device of claim 4 wherein the solid comprises at least one of activated charcoal or carbon black.

6. The analytical device of claim 1 wherein the content of adsorptive material is 1 to 40% by weight relative to the dried total mass of the adhesive.

7. The analytical device of claim 1 wherein the adhesive sets physically.

8. The analytical device of claim 7 wherein the adhesive is solvent-free.

9. The analytical device of claim 8 wherein the adhesive comprises an acrylate adhesive.

10. The analytical device of claim 7 wherein the adhesive is present in the form of an adhesive tape.

11. The analytical device of claim 10 wherein the adhesive tape is adherent on both sides.

12. The analytical device of claim 11 wherein both sides of the adhesive tape are coated identically.

13. The analytical device of claim 1 wherein the analytical device is a test element.

14. The analytical device of claim 1 wherein the analytical device comprises a capillary gap.

15. An analytical device adapted for use with sample liquids, said analytical device comprising

a carrier layer,

and at least two functional layers selected from the group consisting of a detection layer, a separation layer constructed of a membrane or fleece, a transport layer, a layer for the uptake of excess sample, and a spreading layer,

wherein at least two of said functional layers are joined together with the aid of an adhesive,

wherein the adhesive comprises a porous solid as adsorptive material, and wherein the porous solid comprises at least one of an activated charcoal, a carbon black, an aluminum oxide, a silica gel or a zeolithe,

and wherein said adhesive is formed to join together at least two of said functional layers during contact of the liquid sample with the functional layer.

16. The device of claim 15 wherein the solid is not soluble in the adhesive.

17. The analytical device of claim 15 wherein the solid comprises at least one of activated charcoal or carbon black.

18. The analytical device of claim 15 wherein the content of adsorptive material is 1 to 40% by weight relative to the dried total mass of the adhesive.

19. The analytical device of claim 15 wherein the adhesive sets physically.

20. The analytical device of claim 15 wherein the adhesive is solvent-free.

21. The analytical device of claim 15 wherein the adhesive comprises an acrylate adhesive.

22. The analytical device of claim 15 wherein the adhesive is present in the form of an adhesive tape.

23. The analytical device of claim 15 wherein the adhesive tape is adherent on both sides.

24. The analytical device of claim 15 wherein both sides of the adhesive tape are coated identically.

25. The analytical device of claim 15 wherein the analytical device is a test element.

26. The analytical device of claim 15 wherein the analytical device comprises a capillary gap.