Methods and devices for prediction of hypoglycemic events

  • US 6,882,940 B2
  • Filed: 08/10/2001
  • Issued: 04/19/2005
  • Est. Priority Date: 08/18/2000
  • Status: Active Grant
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First Claim
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1. A method for predicting a hypoglycemic event in a subject, said method comprisingdetermining (i) a threshold glucose value that corresponds to said hypoglycemic event, and (ii) a threshold skin conductance and/or temperature value that is correlated with said hypoglycemic event;

  • obtaining a series of glucose measurement values at selected time intervals using a method comprising obtaining a raw signal specifically related to a glucose amount or concentration in the subject for a given time interval, correlating the raw signal with a glucose measurement value indicative of the amount or concentration of glucose present in the subject in said given time interval, repeating said obtaining and correlating to provide a series of glucose measurement values at selected time intervals, predicting a glucose measurement value at a further time interval subsequent to said series of glucose measurement values, and comparing said predicted glucose measurement value to said threshold glucose value, wherein when the a predicted glucose measurement value is less than or equal to the threshold glucose value a hypoglycemic event is predicted;

    measuring skin conductance and/or temperature of the subject concurrently, simultaneously, or sequentially with said obtaining of the series of glucose measurement values, and comparing said skin conductance and/or temperature value or trend of skin conductance and/or temperature values with said threshold skin conductance and/or temperature value to determine whether said skin conductance and/or temperature value or trend of skin conductance and/or temperature values indicates a hypoglycemic event; and

    predicting a hypoglycemic event in said subject when both (i) comparing the predicted glucose measurement value to said threshold glucose value indicates a hypoglycemic event at said further time interval, and (ii) comparing said skin conductance and/or temperature value or trend of skin conductance and/or temperature values with said threshold skin conductance and/or temperature value indicates a hypoglycemic event.

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