Pressure/force computer controlled drug delivery system with automated charging

• US 6,887,216 B2
• Filed: 01/22/2001
• Issued: 05/03/2005
• Est. Priority Date: 04/10/1998
• Status: Expired due to Term

• Current Assignee: Milestone Scientific Incorporated
• Original Assignee: Milestone Scientific Incorporated
• Inventors: Brown, Lawrence, Hochman, Claudia, Lockwood, Michelle, Ascione, Angelo, Johnson, Hardie, Hochman, Mark
• Primary Examiner(s): Thanh, LoAn H.
• Application Number:
  US09/766,910
• Publication Number:
  US 20020052574A1
• Time in Patent Office: 1,562 Days
• Field of Search: 604/151, 604/65, 604/152, 604/187, 604/236, 604/67, 433/80, 128/DIG.12
• US Class Current: 604/67
• CPC Class Codes: A61M 5/1456 with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir
• CPC Class Codes: A61M 5/16854 by monitoring line pressure
• CPC Class Codes: Y10S 128/12 Pressure infusion

Abstract

An automatic injection device includes a drive mechanism and a sensor used to determine an internal characteristic such as a force or internal pressure generated during an injection process. This characteristic is then used as a control parameter by a microprocessor or controller which generates corresponding commands to the drive mechanism. In a particularly advantageous embodiment, the characteristic is used to calculate an exit pressure at which fluid ejected by the device through an elongated tube. The drive mechanism is then operated in such a manner that the exit pressure is maintained at a predetermined level to insure that a patient does not suffer pain and/or tissue damage.

Claims

1. An electronic device for selectively injecting or withdrawing fluid from a patient'"'"'s body comprising:

a reservoir for injecting or collecting said fluid;

a source of therapeutic fluid;

a fluid delivery system having a first end coupled to a said reservoir and a second end adapted to be inserted into the patient'"'"'s body;

a sensor coupled to one of said reservoir, fluid delivery system and electrical drive mechanism for sensing an internal parameter indicative of a force generated by said drive mechanism and internal resistances within said reservoir and said fluid delivery system to said force; and

a controller coupled to said sensor and said electrical drive mechanism, said controller including a calculator for calculating an entry/exit pressure at said second end as a function of said internal parameter, said controller generating said commands for said drive mechanism to control said entry/exit pressure;

wherein said pump in said charging mode is advanced to an empty position and then the piston is retrieved to a full position with the reservoir connected to the source of therapeutic fluid thereby causing said therapeutic fluid to fill said container.

2. The system of claim 1 wherein said controller is adapted to advance said piston after said container reservoir has a predetermined amount of fluid to purge air.

3. The system of claim 1 wherein said delivery system includes a tube extending from said reservoir further comprising a valve coupled to said tube and arranged to allow fluid to be ejected from the syringe reservoir in a first position, and fluid to flow into the syringe reservoir from the fluid source on a second position.

4. The system of claim 1 wherein said container reservoir is a syringe.

5. The system of claim 1 wherein said controller defines an aspiration mode during which said piston is at least partially retrieved to cause fluid to flow toward said piston.

6. The system of claim 5 further comprising a selector controlled by an operator to indicate a desired mode of operation, wherein said controller selects said aspiration mode and said charging mode in response to a position of said selector.

7. The system of claim 6 wherein said selector is adapted to indicate an aspiration operation, and wherein said controller is adapted to move said piston back by a predetermined distance, stop said piston and then move said piston forward again, thereby causing fluid to flow back from the patient and then forward into the patient.

8. The system of claim 7 wherein during said aspiration operation, wherein said controller is adapted to move said piston to the position at which the aspiration operation has started.

9. The system of claim 5 wherein said controller is adapted to select the aspiration mode at the end of an injection, wherein during said aspiration mode said piston is moved back by said controller by a sufficient amount to retrieve fluid from said syringe reservoir.