Continuous non-invasive blood pressure monitoring method and apparatus

• US 6,893,401 B2
• Filed: 05/15/2003
• Issued: 05/17/2005
• Est. Priority Date: 07/27/2001
• Status: Expired due to Term

• Current Assignee: Nellcor Puritan Bennett Ireland
• Original Assignee: VSM Medtech, Ltd.
• Inventors: Dill, Ryan Peter, Hershler, Cecil, Chen, Yunquan, Li, Luya
• Primary Examiner(s): Jones, Mary Beth
• Assistant Examiner(s): Natnithithadha, Navin
• Application Number:
  US10/438,676
• Publication Number:
  US 20030199770A1
• Time in Patent Office: 733 Days
• Field of Search: 600/481, 600/485, 600/486, 600/490, 600492-496, 600500-503
• US Class Current: 600/485
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/02125 of pulse wave propagation time
• CPC Class Codes: A61B 5/4884 inducing physiological or psychological stress, e.g. applications for stress testing
• CPC Class Codes: A61B 5/742 using visual displays A61B5/339 takes precedence

Abstract

A non-invasive apparatus and method for monitoring the blood pressure of a subject detects a pulse signal at both a first and second location on the subject'"'"'s body The elapsed time between the arrival of corresponding points of the pulse signal at the first and second locations is determined. Blood pressure is related to the elapsed time by relationships such as:
P=a+b ln(T),
where a and b are constants dependent upon the nature of the subject and the signal detecting devices. The system can be calibrated by measuring a single pair of reference blood pressure and corresponding elapsed time

Claims

1. Apparatus for blood pressure measurement, the apparatus comprising:

means for measuring a reference blood pressure P₀ and determining a corresponding reference time difference, T₀, the time difference representing a difference in time between the arrival of corresponding points of first and second pulse signals at first and second locations respectively;

means for obtaining a non-linear function relating blood pressure and time difference for the subject based upon the reference blood pressure and the reference time difference; and

,

means for computing an estimated blood pressure, P, at one or more subsequent times, wherein the step for computing the estimated blood pressure includes at least determining a time difference, T, between corresponding points of the first and second pulse signals at the one or more subsequent times and computing the non-linear function of the time difference.

2. A method for obtaining a value representing a blood pressure of a subject, the method comprising:

a step for measuring a reference blood pressure P₀ and determining a corresponding reference time difference, T₀, the time difference representing a difference in time between the arrival of corresponding points of first and second pulse signals at first and second locations respectively;

a step for obtaining a non-linear function relating blood pressure and time difference for the subject based upon the reference blood pressure and the reference time difference; and

,

a step for computing an estimated blood pressure, P, at one or more subsequent times, wherein the step for computing the estimated blood pressure includes at least determining a time difference, T, between corresponding points of the first and second pulse signals at the one or more subsequent times and computing the non-linear function of the time difference.

3. A method according to claim 2 wherein the step for obtaining the non-linear function comprises determining at least two parameters of the non-linear function.

4. A method according to claim 3 wherein the step for obtaining the non-linear function comprises determining a first one of the at least two parameters as a predetermined function of the reference time difference.

5. A method according to claim 4 wherein the step for obtaining the non-linear function comprises determining a second one of the at least two parameters based upon the first one of the at least two parameters, the reference blood pressure and the reference time difference.

6. A method according to claim 5 wherein obtaining the first parameter comprises performing the calculation $b=\frac{P_0-c_1}{\ln }$

(T0)+c2

where b is the first parameter and c1 and c2 are constants, or a calculation mathematically equivalent thereto.

7. A method according to claim 6 wherein obtaining the second parameter comprises performing the calculation:

a=c₁+c₂b

where a is the second parameter, or a calculation mathematically equivalent thereto.

8. A method according to claim 5 wherein obtaining the first parameter comprises performing the calculation:

b=c₃T₀+c₄

where b is the first parameter and c3 and c4 are predetermined constants, or a calculation mathematically equivalent thereto.

9. A method according to claim 8 wherein obtaining the second parameter comprises performing the calculation:

a=P₀−

b ln(T₀)

where a is the second parameter, or a calculation mathematically equivalent thereto.

10. A method according to claim 5 wherein the non-linear function comprises a logarithmic function of T and, in the non-linear function, the logarithmic function of T is multiplied by the first one of the parameters.

11. A method according to claim 10 wherein, the non-linear function comprises adding the second one of the parameters to a result.

12. A method according to claim 4 wherein the predetermined function is a function obtained by:

collecting multiple pairs of reference time difference and reference blood pressure for each of a plurality of reference subjects;

for each of the plurality of reference subjects fitting the non-linear function to the multiple pairs of reference time difference and reference blood pressure to obtain values for the first and second parameters for each of the plurality of reference subjects; and

,

fitting a suitable curve to obtain the predetermined function.

13. A method according to claim 12 wherein the suitable curve comprises a linear trend line.

14. A method according to claim 13 wherein the plurality of reference subjects is selected by picking reference subjects for whom a measure of fit between the non-linear function and the multiple pairs of reference time difference and reference blood pressure exceeds a threshold.

15. A method according to claim 14 wherein the measure of fit comprises an R-squared value.

16. A method according to claim 2 wherein the non-linear function comprises a logarithmic function of T.

17. A method according to claim 2 wherein the value representing a blood pressure of a subject represents a systolic blood pressure of the subject and the corresponding points on the first and second signals are in parts of the first and second signals corresponding to a systolic portion of the subject'"'"'s pulse.

18. A method according to claim 2 wherein the value representing a blood pressure of a subject represents a diastolic blood pressure of the subject and the corresponding points on the first and second signals are in parts of the first and second signals corresponding to a diastolic portion of the subject'"'"'s pulse.

19. A method according to claim 2 wherein the non-linear function is a monotonically decreasing function of the time difference.

20. A program product comprising a medium carrying signals embodying instructions which, when executed by a data processor cause the data processor to perform a method according to claim 2.

21. A program product comprising a medium carrying signals embodying instructions which, when executed by a data processor cause the data processor to perform a method according to claim 19.

22. A program product comprising a medium carrying signals embodying instructions, the instructions capable of being executed by a data processor to provide

means for measuring a reference blood pressure P₀ and determining a corresponding reference time difference, T₀, the time difference representing a difference in time between the arrival of corresponding points of first and second pulse signals at first and second locations respectively;

means for obtaining a non-linear function relating blood pressure and time difference for the subject based upon the reference blood pressure and the reference time difference; and

,

means for computing an estimated blood pressure, P, at one or more subsequent times, wherein the step for computing the estimated blood pressure includes at least determining a time difference, T, between corresponding points of the first and second pulse signals at the one or more subsequent times and computing the non-linear function of the time difference.