Bioadhesive drug delivery system

  • US 6,899,890 B2
  • Filed: 03/20/2002
  • Issued: 05/31/2005
  • Est. Priority Date: 03/20/2002
  • Status: Active Grant
First Claim
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1. An essentially pH neutral vaginal drug delivery system, which comprises:

  • an essentially pH neutral emulsion having globules having two phases, an internal water-soluble phase and an external water-insoluble phase or film;

    said internal water-soluble phase comprises an acidic buffered phase containing a therapeutically active drug or drugs, wherein the acidic buffered phase comprises said therapeutically active drug or drugs either alone or in combination with an additional buffering agent;

    wherein the acidic buffered phase is isotonic, hypertonic, or hypotonic; and

    wherein the globules have a particle size ranging from about 0.1 microns to about 100 microns.

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