Non-invasive localization of a light-emitting conjugate in a mammal

  • US 6,916,462 B2
  • Filed: 12/16/2002
  • Issued: 07/12/2005
  • Est. Priority Date: 07/01/1994
  • Status: Expired due to Fees
First Claim
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1. A non-invasive method for detecting a transformed, microorganism in a mammalian subject, comprising:

  • administering to the subject a microorganism transformed with a heterologous gene encoding a fluorescent protein, wherein said subject comprises opaque tissue, and measuring photon emission through opaque tissue of said subject wherein said photon emission is mediated by fluorescent protein expressed from said heterologous gene.

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