Amino ceramide-like compounds and therapeutic methods of use
DCFirst Claim
Patent Images
1. A compound of formula I:
-
a stereoisomer, a pharmaceutically acceptable salt or a mixture thereof, whereinR1 is a phenyl, a substituted phenyl group, a branched aliphatic group, or a 7-15 carbons long alkyl chain or a 7-15 carbons long alkenyl chain with a double bond next to the kernel;
R2 is an alkyl group 6, 7, or 8 carbons long; and
R3 is a pyrrolidine, azetidine, morpholine or piperidine, in which the nitrogen atom is attached to the kernel.
2 Assignments
Litigations
0 Petitions
Accused Products
Abstract
The present invention provides amino ceramide-like compounds which inhibit glucosyl ceramide (GlyCer) formation by inhibiting the enzyme GlyCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
56 Citations
14 Claims
-
1. A compound of formula I:
-
a stereoisomer, a pharmaceutically acceptable salt or a mixture thereof, wherein R1 is a phenyl, a substituted phenyl group, a branched aliphatic group, or a 7-15 carbons long alkyl chain or a 7-15 carbons long alkenyl chain with a double bond next to the kernel;
R2 is an alkyl group 6, 7, or 8 carbons long; and
R3 is a pyrrolidine, azetidine, morpholine or piperidine, in which the nitrogen atom is attached to the kernel. - View Dependent Claims (2, 3, 4, 5, 6, 7)
-
-
8. A compound of formula I:
-
or a stereoisomer, pharmaceutically acceptable salt, or a mixture thereof, wherein R1 is a substituted or unsubstituted phenyl group, a branched aliphatic group, or a 7-15 carbons long alkyl chain or a 7-15 carbons long alkenyl chain with a double bond next to the kernel;
R2 is an alkyl group 6, 7, or 8 carbons long; and
R3 is pyrrolidine, in which the nitrogen atom is attached to the kernel. - View Dependent Claims (9, 10, 11, 12, 13, 14)
-
Specification