Method and apparatus for predicting recurring ventricular arrhythmias

• US 6,922,585 B2
• Filed: 04/05/2002
• Issued: 07/26/2005
• Est. Priority Date: 04/05/2002
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Sharma, Vinod, Zhou, Xiaohong, Olson, Walter H.
• Primary Examiner(s): EVANISKO, GEORGE ROBERT
• Application Number:
  US10/117,465
• Publication Number:
  US 20030191403A1
• Time in Patent Office: 1,208 Days
• Field of Search: 600515-518, 607/4, 607/5, 607/9, 607/14, 607/17, 607/19
• US Class Current: 600/518
• CPC Class Codes: A61B 5/361 Detecting fibrillation
• CPC Class Codes: A61B 5/363 Detecting tachycardia or bradycardia
• CPC Class Codes: A61B 5/4035 Evaluating the autonomic nervous system
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/3962 in combination with another heart therapy
• CPC Class Codes: A61N 1/39622 Pacing therapy

Abstract

An implantable medical device and method are provided for assessing autonomic tone and risk factors associated with arrhythmias and, based on this assessment, an early recurrence of ventricular tachycardia or ventricular fibrillation is predicted. Specifically, changes in R—R interval, heart rate variability, patient activity, and myocardial ischemia are measured prior to and after a detected an arrhythmia episode. A recurrence score is calculated as a weighted sum of measured parameters and compared to a prediction criterion. The prediction criterion may be a preset threshold score or an individualized episode template based on previously calculated recurrence scores associated with recurring episodes. Stored parameters and episode-related data may be downloaded for offline analyses for optimizing prediction criteria and monitoring patient status.

Claims

1. A method for predicting a recurring arrhythmia comprising:

detecting an arrhythmia episode;

measuring a number of parameters based on said arrhythmia episode indicative of autonomic tone;

determining whether the episode is a recurring episode;

determining changes in the parameters prior to onset of the episode and subsequent to termination of the episode;

calculating a recurrence score in response to the determined changes; and

predicting an arrhythmia event with high probabilistic certainty based on said recurrence score.

2. The method of claim 1 wherein said method of detecting includes measuring R—

R intervals and P—

P intervals.

3. The method of claim 1 wherein said method of measuring includes collecting R—

R interval templates.

4. The method of claim 1 wherein said method includes collecting a heart rate variability (HRV) template.

5. The method of claim 1 wherein said method includes collecting an activity template.

6. The method according to claim 5 wherein a correlation between a physical activity and an R—

R interval is included in said activity template.

7. The method of claim 1 wherein said collecting method includes determining indicators of autonomic tone and risk factors for VT and VF recurrence.

8. The method of claim 1 wherein said method of predicting includes comparing said recurrence score with a threshold, a VT or VF episode.

9. The method of claim 1 wherein said method of predicting includes using a range of value benchmarks to predict VT or VF episodes if the recurrence score falls within said range of value benchmarks.

10. The method of claim 1, wherein determining changes comprises:

determining changes in RR intervals at onset of the episode and subsequent to termination of the episode;

determining changes in activity levels at onset of the episode and subsequent to termination of the episode; and

determining changes in heart rate variability at onset of the episode and subsequent to termination of the episode.

11. The method of claim 10, wherein the recurrence score is a weighted sum of the determined changes.

12. A medical device for predicting a recurring arrhythmia in a patient, comprising:

a first sensor sensing cardiac signals;

a second sensor sensing activity of the patient; and

a microprocessor connected to the sensors determining whether an arrhythmia episode has occurred and whether the arrhythmia episode is a recurring episode, and determining parameters based on the arrhythmia episode indicative of autonomic tone, wherein the microprocessor determines changes In the parameters prior to onset of the episode and subsequent to termination of the episode, calculates a recurrence score in response to the determined changes, and predicts an arrhythmia event in response to the recurrence score.

13. The device of claim 12, wherein the microprocessor determines changes in RR intervals at onset of the episode and subsequent to termination of the episode, determines changes in activity levels at onset of the episode and subsequent to termination of the episode, and determines changes in heart rate variability at onset of the episode and subsequent to termination of the episode.