Non-invasive localization of a light-emitting conjugate in a mammal

  • US 6,923,951 B2
  • Filed: 12/16/2002
  • Issued: 08/02/2005
  • Est. Priority Date: 07/01/1994
  • Status: Expired due to Fees
First Claim
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1. A non-invasive method for detecting transformed eukaryotic cells in a mammalian subject, comprising:

  • administering to the subject eukaryotic cells transformed with a heterologous gene encoding a bioluminescent protein, wherein said subject comprises opaque tissue, and measuring photon emission through opaque tissue of said subject wherein said photon emission is mediated by bioluminescent protein expressed from said heterologous gene.

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