Cushioning wax beads for making solid shaped articles

  • US 6,923,984 B1
  • Filed: 07/26/2000
  • Issued: 08/02/2005
  • Est. Priority Date: 09/17/1999
  • Status: Expired due to Term
First Claim
Patent Images

1. In a solid shaped compressed article, said solid shaped compressed article containing a biologically active ingredient and a hydrocarbon wax or natural wax, the improvement wherein:

  • said solid shaped compressed article contains the biologically active ingredient in the form of biologically active ingredient-loaded beads with a brittle coating, said solid shaped article further comprises biologically inactive cushioning beads of a size of about 0.5 to 2 mm for protecting said brittle coating during compression or compaction, wherein said biologically inactive cushioning beads comprise at least one compressible cushioning component consisting essentially of a microcrystalline hydrocarbon wax or a natural wax, the said wax being at least 30% by weight of the biologically inactive cushioning beads, and optionally up to 70% by weight of another biologically inactive compressible cushioning component or pharmaceutically acceptable excipient, and wherein the weight ratio of the biologically inactive cushioning beads to the coated biologically active ingredient-loaded beads is between 30;

    70 and 70;

    30.

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