Pharmaceutical compositions for the coordinated delivery of NSAIDs

CAFC
  • US 6,926,907 B2
  • Filed: 05/31/2002
  • Issued: 08/09/2005
  • Est. Priority Date: 06/01/2001
  • Status: Active Grant
First Claim
Patent Images

1. A pharmaceutical composition in unit dose form suitable for oral administration to a patient, comprising:

  • (a) an acid inhibitor present in an amount effective to raise the gastric pH of said patient to at least 3.5 upon the administration of one or more of said unit dosage forms;

    (b) a non-steroidal anti-inflammatory drug (NSAID) in an amount effective to reduce or eliminate pain or inflammation in said patient upon administration of one or more of said unit dosage forms;

    and wherein said unit dosage form provides for coordinated release such that;

    i) said NSAID is surrounded by a coating that, upon ingestion of said unit dosage form by said patient, prevents the release of essentially any NSAID from said dosage form unless the pH of the surrounding medium is 3.5 or higher;

    ii) at least a portion of said acid inhibitor is not surrounded by an enteric coating and, upon ingestion of said unit dosage form by said patient, is released regardless of whether the pH of the surrounding medium is below 3.5 or above 3.5.

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