Ultrasonic diagnosing/treating device and method therefor

• US 6,929,609 B2
• Filed: 01/18/2002
• Issued: 08/16/2005
• Est. Priority Date: 01/18/2001
• Status: Expired due to Term

• Current Assignee: FUJIFILM Healthcare Corp. (Fujifilm Holdings Corporation)
• Original Assignee: Hitachi Medical Corporation (Hitachi, Ltd.)
• Inventors: Asafusa, Katsunori
• Primary Examiner(s): IMAM, ALI M
• Application Number:
  US10/446,028
• Publication Number:
  US 20040059219A1
• Time in Patent Office: 1,306 Days
• Field of Search: 600407-472, 601 2- 4, 424 95- 952, 604/20, 604/22, 604/290, 604/424
• US Class Current: 600/439
• CPC Class Codes: A61B 2017/22082 after introduction of a substance
• CPC Class Codes: A61B 2017/22088 ultrasound absorbing, drug activated by ultrasound
• CPC Class Codes: A61B 2090/378 using ultrasound
• CPC Class Codes: A61B 8/0833 involving detecting or locating foreign bodies or organic structures
• CPC Class Codes: A61B 8/481 involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream analysis of echo signal exploiting properties of a contrast enhancer in devices for short-range imaging with acoustic waves G01S7/52039
• CPC Class Codes: A61M 37/0092 using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis

Abstract

An ultrasonic diagnostic/treatment device includes a first ultrasonic wave irradiator that transmits a first ultrasonic wave signal to an organism for obtaining an image and receives a received wave signal corresponding to an echo signal of the first ultrasonic wave signal, a processor that processes the received wave signal to obtain diagnostic information, a second ultrasonic wave irradiator that irradiates the organism with a second ultrasonic wave signal for destroying medicine-containing microcapsules administered to the organism, and a controller that controls the second ultrasonic wave irradiator on the basis of the diagnostic information obtained by the first ultrasonic wave irradiator.

Claims

1. An ultrasonic diagnostic/treatment device including:

first ultrasonic wave irradiation means that transmits, to an organism, a first ultrasonic wave signal for obtaining an image and receives a received wave signal corresponding to an echo signal of the first ultrasonic wave signal;

means that processes the received wave signal to obtain diagnostic information;

second ultrasonic wave irradiation means that irradiates, the organism with a second ultrasonic wave signal for destroying medicine-containing microcapsules administered to the organism; and

control means that controls the second ultrasonic wave irradiation means on the basis of the diagnostic information obtained by the first ultrasonic wave irradiation means.

2. The ultrasonic diagnostic/treatment device of claim 1, wherein the control means includes irradiation timing generation means that generates an irradiation timing schedule of the second ultrasonic wave signal using the diagnostic information obtained by the first ultrasonic wave irradiation means.

3. The ultrasonic diagnostic/treatment device of claim 2, wherein the irradiation timing generation means includes image display means that displays an image of the echo signals from the first ultrasonic wave signals comprising a harmonic component of the ultrasonic waves reflected by the microcapsules.

4. The ultrasonic diagnostic/treatment device of claim 2, wherein the irradiation timing generation means includes image display means that displays a tomogram of the organism superposed with an image of the echo signal obtained by the first ultrasonic wave signal comprising a harmonic component of the ultrasonic waves reflected by the microcapsules.

5. The ultrasonic diagnostic/treatment device of claim 2, wherein the irradiation timing generation means includes audio generation means that generates audio relating to the generation of the second ultrasonic wave signal on the basis of temporal changes in the amount of the echo signal changing due to the microcapsules flowing to a diseased part in the organism.

6. The ultrasonic diagnostic/treatment device of claim 2, wherein the irradiation timing generation means includes image display means that displays temporal changes in the amount of the echo signal changing due to the microcapsules flowing to a diseased part in the organism.

7. The ultrasonic diagnostic/treatment device of claim 6, wherein the image display means displays numerical values of the temporal changes in the echo signal amount.

8. The ultrasonic diagnostic/treatment device of claim 6, wherein the image display means displays a message relating to the generation of the second ultrasonic wave signal on the basis of a comparison between temporal changes in the monitored echo signal amount and a preset, predetermined value.

9. The ultrasonic diagnostic/treatment device of claim 6, wherein the image display means includes means that generates a graph of a time intensity curve showing the echo signal amount along one axis and time along the other axis.

10. The ultrasonic diagnostic/treatment device of claim 9, wherein the image display means superposes the graph of a time intensity curve with an image of the echo signal comprising a harmonic component of the ultrasonic waves reflected from the microcapsules or a tomogram of across section of the organism or both in the display.

11. The ultrasonic diagnostic/treatment device of claim 9, wherein the image display means displays in parallel the graph of a time intensity curve and an image of the echo signal comprising a harmonic component of the ultrasonic waves reflected from the microcapsules or a tomogram of a cross section of the organism or both.

12. The ultrasonic diagnostic/treatment device of claim 9, wherein the image display means switches display between the graph of a time intensity curve and an image of the echo signal comprising a harmonic component of the ultrasonic waves reflected from the microcapsules or a tomogram of a cross section of the organism or both.

13. The ultrasonic diagnostic/treatment device of claim 2, wherein the irradiation timing generation means includes image display means that displays undestroyed microcapsules measured by the first ultrasonic wave signal when the ultrasonic wave signal has been switched from the second ultrasonic wave signal to the first ultrasonic wave signal.

14. The ultrasonic diagnostic/treatment device of claim 13, further including means that adjusts the frequency and intensity of the second ultrasonic wave signal on the basis of the undestroyed microcapsules.

15. The ultrasonic diagnostic/treatment device of claim 2, wherein the irradiation timing generation means includes means that freezes the display of an image at a position at which the diseased part of the organism that is to be treated is best displayed by image display means when the ultrasonic wave signal is switched from the first ultrasonic wave signal to the second ultrasonic wave signal.

16. The ultrasonic diagnostic/treatment device of claim 1, wherein the transmission intensity P1 of the first ultrasonic wave signal is 0<

P1 1[W/cm²] and the transmission intensity P2 of the second ultrasonic wave signal is 0<

P2 5[W/cm²].

17. The ultrasonic diagnostic/treatment device of claim 1, wherein the ratio of the transmission intensity P1 of the first ultrasonic wave signal and the transmission intensity P2 of the second ultrasonic wave signal is P1=m×

P2 (where m is 0<

m 0.2).

18. The ultrasonic diagnostic/treatment device of claim 1, wherein the control means controls the focus range of the ultrasonic waves irradiated to the organism from the second ultrasonic wave irradiation means.

19. An ultrasonic diagnostic/treatment device including:

a probe that transmits ultrasonic waves to an organism to which medicine-containing microcapsules have been administered and that receives the echo thereof;

means that sets, in a transmission wave signal generation unit, a first ultrasonic wave signal for obtaining an image of the organism;

means that receives the echo corresponding to the first ultrasonic wave signal as a signal and conducts processing for image-displaying the echo signal;

means that acquires the processed echo signal as diagnostic information;

means that sets, in the transmission wave signal generation unit, a second ultrasonic wave signal that can destroy the microcapsules;

means that causes the probe to transmit the second ultrasonic wave signal to the organism; and

means that switches between the first ultrasonic wave signal and the second ultrasonic wave signal on the basis of the obtained diagnostic information.

20. An ultrasonic diagnostic/treatment device including:

first ultrasonic wave irradiation means that transmits, to an organism to which at least two different types of medicine-containing microcapsules have been administered, a first ultrasonic wave signal for obtaining an image and receives a received wave signal corresponding to an echo signal of the first ultrasonic wave signal;

means that processes the received wave signal to obtain diagnostic information;

second ultrasonic wave irradiation means that irradiates the organism with a second ultrasonic wave signal for destroying the microcapsules administered to the organism; and

control means that controls the second ultrasonic wave irradiation means on the basis of the obtained diagnostic information.

21. The ultrasonic diagnostic/treatment device of claim 20, further including

means that inputs the order in which the plural types of microcapsules are injected and the intensity and frequency of ultrasonic waves transmitted to each of the microcapsules,

means that stores the inputted injection order and the intensity and frequency of the ultrasonic waves per microcapsule, and

control means that controls the second ultrasonic wave irradiation means according to the second ultrasonic wave signal that is set for each microcapsule on the basis of the stored injection order and the intensity and frequency of the ultrasonic waves.

22. The ultrasonic diagnostic/treatment device of claim 21, further including means that controls the injector on the basis of the order set by the input means.

23. An ultrasonic diagnostic/treatment device including:

a probe that transmits ultrasonic waves to an organism to which at least two types of medicine-containing microcapsules have been administered and that receives the echo thereof;

means that sets, in a transmission wave signal generation unit, a first ultrasonic wave signal for obtaining an image of the organism;

means that receives the echo corresponding to the first ultrasonic wave signal as a signal and conducts processing for image-displaying the echo signal;

means that acquires the processed echo signal as diagnostic information;

means that sets, in the transmission wave signal generation unit, a second ultrasonic wave signal that can destroy the microcapsules;

means that causes the probe to transmit the second ultrasonic wave signal to the organism on the basis of the acquired diagnostic information; and

means that switches between the first ultrasonic wave signal and the second ultrasonic wave signal on the basis of the obtained diagnostic information.

24. An ultrasonic diagnostic and treatment method including the steps of:

transmitting, to an organism, a first ultrasonic wave signal for obtaining an image and receiving a received wave signal corresponding to the echo signal of the first ultrasonic wave signal;

processing the received wave signal to obtain diagnostic information; and

controlling a second ultrasonic wave signal for destroying medicine-containing microcapsules administered to the organism on the basis of the obtained diagnostic information.

25. The ultrasonic diagnostic and treatment method of claim 24, wherein the control step includes an irradiation timing generation step for setting the timing of transmission of the second ultrasonic wave signal using the obtained diagnostic information.

26. The ultrasonic diagnostic and treatment method of claim 25, wherein the irradiation timing generation step includes a step for displaying an image of the echo signal from the first ultrasonic wave signal, comprising a harmonic component of the ultrasonic waves reflected by the microcapsules.

27. The ultrasonic diagnostic and treatment method of claim 26, wherein the image display step includes a step for generating a graph of a time intensity curve showing the echo signal amount on one axis and time on the other axis, to display the generated graph.

28. The ultrasonic diagnostic and treatment method of claim 27, wherein the image display step superposes display of the graph of a time intensity curve with an image of the echo signal comprising a harmonic component of the ultrasonic waves reflected from the microcapsules or a tomogram of a cross section of the organism or both.

29. The ultrasonic diagnostic and treatment method of claim 27, wherein the image display step displays in parallel the graph of a time intensity curve and an image of the echo signal comprising a harmonic component of the ultrasonic waves reflected from the microcapsules or a tomogram of across section of the organism or both.

30. The ultrasonic diagnostic and treatment method of claim 27, wherein the image display step switches display between the graph of a time intensity curve and an image of the echo signal comprising a harmonic component of the ultrasonic waves reflected from the microcapsules or a tomogram of a cross section of the organism or both.

31. The ultrasonic diagnostic and treatment method of claim 25, wherein the irradiation timing generation step includes a step that freezes display of the image at the position at which the diseased part of the organism that is to be treated is best displayed by image display means when the ultrasonic wave signal has been switched from the first ultrasonic wave signal to the second ultrasonic wave signal.

32. The ultrasonic diagnostic and treatment method of claim 25, wherein the irradiation timing generation step includes a step for superposing and displaying a tomogram of the organism with an image of the echo signal obtained by the first ultrasonic wave signal comprising a harmonic component of the ultrasonic waves reflected by the microcapsules.

33. The ultrasonic diagnostic and treatment method of claim 25, wherein the irradiation timing generation step includes a step for generating audio relating to the generation of the second ultrasonic wave signal on the basis of temporal changes in the amount of the echo signal changing due to the microcapsules flowing to a diseased part in the organism.

34. The ultrasonic diagnostic and treatment method of claim 25, wherein the irradiation timing generation includes a step for displaying temporal changes in the amount of the echo signal changing due to the microcapsules flowing to a diseased part in the organism.

35. The ultrasonic diagnostic and treatment method of claim 24, wherein a transmission intensity P1 of the first ultrasonic wave signal is 0<

P1 1[W/cm²] and a transmission intensity P2 of the second ultrasonic wave signal is 1<

P2 5[W/cm²].

36. The ultrasonic diagnostic and treatment method of claim 24, wherein the ratio of the transmission intensity P1 of the first ultrasonic wave signal and the transmission intensity P2 of the second ultrasonic wave signal is P1=m×

P2 (where m is 0<

m 0.2).

37. The ultrasonic diagnostic and treatment method of claim 24, further including a step for controlling the focus range of the second ultrasonic wave irradiation means.

38. An ultrasonic diagnostic and treatment method including the steps of:

setting, in a transmission wave signal generation unit, a first ultrasonic wave signal to be transmitted to an organism to which medicine-containing microcapsules have been administered, and by receiving the echo thereof obtaining an image of the organism;

receiving the echo corresponding to the first ultrasonic wave signal as a signal and conducting processing for image-displaying the echo signal;

acquiring the processed echo signal as diagnostic information;

setting, in the transmission wave signal generation unit, a second ultrasonic wave signal that can destroy the microcapsules;

transmitting the second ultrasonic wave signal to the organism; and

switching between the first ultrasonic wave signal and the second ultrasonic wave signal on the basis of the obtained diagnostic information.

39. An ultrasonic diagnostic and treatment method including the steps of:

transmitting, to an organism, a first ultrasonic wave signal for obtaining an image and receiving a received wave signal corresponding to the echo signal of the first ultrasonic wave signal;

processing the received wave signal to obtain diagnostic information;

transmitting, to the organism, a second ultrasonic wave signal for destroying at least two types of medicine-containing microcapsules that have been administered to the organism;

switching, on the basis of the obtained diagnostic information, from the first ultrasonic wave signal to the second ultrasonic wave signal for destroying at least two types of medicine-containing microcapsules that have been administered to the organism, and transmitting the second ultrasonic wave signal to the organism.

40. The ultrasonic diagnostic and treatment method of claim 39, further including the steps of

inputting an order in which the plural types of microcapsules are injected and the intensity and frequency of ultrasonic waves transmitted for each of the microcapsules,

storing the inputted injection order and the intensity and frequency of the ultrasonic waves per microcapsule, and

controlling the second ultrasonic wave irradiation means according to the second ultrasonic wave signal that is set for each microcapsule on the basis of the stored injection order and the intensity and frequency of the ultrasonic waves.

41. The ultrasonic diagnostic and treatment method of claim 40, further including a step for controlling the injector on the basis of the order set by the input step.

42. An ultrasonic diagnostic and treatment method including the steps of:

transmitting ultrasonic waves to an organism to which at least two types of medicine-containing microcapsules have been administered, receiving an echo thereof, and setting, in a transmission wave signal generation unit, a first ultrasonic wave signal for obtaining an image of the organism;

receiving the echo corresponding to the first ultrasonic wave signal as a signal and conducting processing for image-displaying the echo signal;

acquiring the processed echo signal as diagnostic information;

setting, in the transmission wave signal generation unit, a second ultrasonic wave signal that can destroy for each microcapsule;

transmitting the second ultrasonic wave signal to the organism; and

switching between the first ultrasonic wave signal and the second ultrasonic wave signal on the basis of the obtained diagnostic information.