Veterinary treatment of ophthalmic disease in animals using topical tacrolimus

• US 6,930,127 B2
• Filed: 06/18/2003
• Issued: 08/16/2005
• Est. Priority Date: 08/15/2002
• Status: Expired due to Term

• Current Assignee: EVP Pharmaceuticals, Inc. (Covetrus, Inc.)
• Original Assignee: Eaton Veterinary Laboratories, Inc.
• Inventors: Stiles, Kris R.
• Primary Examiner(s): FAY, ZOHREH A
• Application Number:
  US10/465,293
• Publication Number:
  US 20040034053A1
• Time in Patent Office: 790 Days
• Field of Search: 514/291, 514/443, 514/912, 514/445
• US Class Current: 514/445
• CPC Class Codes: A61K 31/4745 condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines yohimbine derivatives, vinblastine A61K31/475; ergoline derivatives A61K31/48
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears

Abstract

A composition and method for veterinary treatment of ophthalmic immune-mediated inflammatory conditions in animals such as conjunctival disorders of the third eyelid, keratoconjunctivitis sicca (KCS), chronic superficial keratitis (CSK), feline eosinophilic keratoconjunctivitis, allergic conjunctivitis, blepharoconjunctivitis, ocular rosacea, viral conjunctivitis, uveitis and phacoanaphylactic endophthalmitis involves the topical administration of tacrolimus to the eye in a pharmaceutically acceptable lubricant vehicle. The composition of the invention includes about 0.00001% to 10.0% tacrolimus by weight in a pharmaceutically acceptable oil-based solution or ointment and may be administered to the third eyelid of an affected animal.

Claims

1. A method of treating pannus in canines having said disease and comprising the steps of:

a) providing a quantity of a composition consisting essentially of an effective amount of tacrolimus in a pharmaceutically acceptable non-aqueous lubricant vehicle; and

b) administering a quantity of said composition to the third eyelid of an affected canine.

2. The method as set forth in claim 1, wherein:

a) said tacrolimus is present in a concentration of from about 0.00001% to about 10.0% by weight.

3. The method as set forth in claim 1, wherein said lubricating vehicle is selected from the group consisting essentially of corn oil, olive oil, mineral oil, cottonseed oil, sesame oil, canola oil, peanut oil, safflower oil, sunflower oil, polyoxethylated castor oil, petrolatum, mineral oil or mixtures thereof.