Left ventricular conduits to coronary arteries and methods for coronary bypass

• US 6,949,080 B2
• Filed: 08/15/2002
• Issued: 09/27/2005
• Est. Priority Date: 01/30/1998
• Status: Expired due to Fees

• Current Assignee: Horizon Technology Funding Co. LLC (Horizon Technology Finance Management LLC)
• Original Assignee: Percardia, Inc.
• Inventors: Kamm, Roger D., Shim, Eun Bo, Briefs, Nancy, Furnish, Simon, Wilk, Peter J., Melsky, Gerald, Renati, Richard, Burkhoff, Daniel, Hall, Todd A., Wolf, Scott J., Phelps, David Y., Furnish, Greg R., Santamore, William, Evans, Stephen
• Primary Examiner(s): Bianco, Patricia
• Application Number:
  US10/218,916
• Publication Number:
  US 20030055371A1
• Time in Patent Office: 1,139 Days
• Field of Search: 604 8- 10, 604 27- 30, 604/500, 604506- 9, 604/511, 604264- 66, 604/523, 604530- 32, 604/537, 604285- 88, 128/898, 606/108, 606/151, 606153- 54, 606/159, 606/167, 606/170, 606184- 85, 606191- 92, 606194- 95, 606198-200, 623/1.1, 623 111- 112, 623/1.15, 623 117- 118, 623 12- 125, 623 13- 132, 623/1.36, 623 138- 148, 623/1.49, 623/11.11, 623/23.64, 623 2367- 2368, 623 237- 2371, 623 2375- 2376, 623/920, 623/921, 623/915, 623/916, 424/400, 424422- 26, 427/2.1, 427/2.14, 427 221- 222, 427/2.24, 427/2.25, 427 228- 229
• US Class Current: 604/8
• CPC Class Codes: A61B 17/0057 Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect sutures A61B17/04; closing rectum or urethra near body surface A61F2/0009
• CPC Class Codes: A61B 17/11 for performing anastomosis; Buttons for anastomosis
• CPC Class Codes: A61B 17/3468 for implanting or removing devices, e.g. prostheses, implants, seeds, wires devices for implanting seeds A61M37/0069
• CPC Class Codes: A61B 2017/00247 Making holes in the wall of the heart, e.g. laser Myocardial revascularization
• CPC Class Codes: A61B 2017/00252 for by-pass connections, i.e. connections from heart chamber to blood vessel or from blood vessel to blood vessel
• CPC Class Codes: A61B 2017/00637 for sealing trocar wounds through abdominal wall
• CPC Class Codes: A61B 2017/00654 entirely comprised between the two sides of the opening
• CPC Class Codes: A61B 2017/1107 for blood vessels
• CPC Class Codes: A61B 2017/1135 End-to-side connections, e.g. T- or Y-connections Y-shaped blood vessel prostheses A61F2002/065
• CPC Class Codes: A61B 2018/00392 Transmyocardial revascularisation
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/026 Measuring blood flow A61B3/1233, A61B3/1241 take precedence
• CPC Class Codes: A61B 5/6862 Stents
• CPC Class Codes: A61B 5/6876 Blood vessel
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61F 2/064 with special features to facilitate anastomotic coupling anastomosis of natural blood vessels A61B17/11
• CPC Class Codes: A61F 2/2493 Transmyocardial revascularisation [TMR] devices
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2/94 Stents retaining their form, i.e. not being deformable, after placement in the predetermined place
• CPC Class Codes: A61F 2002/8486 : provided on at least one of the ends
• CPC Class Codes: A61F 2002/91508 : the meander having a difference in amplitude along the band
• CPC Class Codes: A61F 2002/91516 : the meander having a change in frequency along the band
• CPC Class Codes: A61F 2002/91525 : within the whole structure different bands showing different meander characteristics, e.g. frequency or amplitude
• CPC Class Codes: A61F 2002/91533 : characterised by the phase between adjacent bands
• CPC Class Codes: A61F 2002/91575 : connected peak to trough
• CPC Class Codes: A61F 2220/0008 : Fixation appliances for connecting prostheses to the body
• CPC Class Codes: A61F 2220/0016 : with sharp anchoring protrusions, e.g. barbs, pins, spikes
• CPC Class Codes: A61F 2250/0002 : for data transfer
• CPC Class Codes: A61F 2250/0039 : differing in diameter
• CPC Class Codes: A61F 2250/0067 : Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61M 27/002 : Implant devices for drainage of body fluids from one part of the body to another intraocular A61F9/00781; middle ear A61F11/202

Abstract

A stent suitable for implantation in myocardial tissue to enhance perfusion therein may include a tubular member having first and second ends and a lumen. The first end of the stent may be configured to pierce myocardial tissue and the lumen may be configured to be placed in flow communication with a coronary vessel. The stent may further include a means for retaining the tubular member within the myocardial tissue. A method for implanting the stent may include positioning the first end of the stent at a desired implantation site and applying force to the second end of the stent to implant the stent within the myocardial tissue. The method may further include engaging the means for retaining with the myocardial tissue to retain the stent in position.

Claims

1. A stent suitable for implantation in myocardial tissue to enhance perfusion therein, the stent comprising:

a tubular member having first and second ends and a lumen, the first end configured to pierce myocardial tissue and the lumen configured to be placed in flow communication with a coronary vessel; and

means for retaining the tubular member within the myocardial tissue.

2. The stent as defined in claim 1 further comprising a bioactive agent.

3. The stent as defined in claim 2 wherein the tubular member has a surface that carries the bioactive agent.

4. The apparatus as defined in claim 2 wherein the bioactive agent comprises an angiogenic growth factor.

5. The stent as defined in claim 1 wherein the tubular member further includes a plurality of apertures extending from the lumen to an exterior lateral surface of the stent.

6. The stent as defined in claim 5 wherein the first end further comprises a portion defining an opening that communicates with the lumen.

7. The stent as defined in claim 1 wherein the lumen extends longitudinally from the first end to the second end.

8. The stent as defined in claim 1 wherein the means for retaining comprises a flange that abuts against a tissue surface.

9. The stent as defined in claim 8 wherein the means for retaining comprises a plurality of tines that extend radially outward from the exterior surface to engage the myocardial tissue.

10. The stent as defined in claim 1 wherein the tubular member comprises a bioresorbable material.

11. The stent as defined in claim 10 wherein the bioresorbable material is impregnated with a bioactive agent.

12. The stent as defined in claim 1 wherein the means for retaining comprises at least one barb projecting from an exterior surface of the tubular member.

13. The apparatus as defined in claim 1 wherein the means for retaining comprises a plurality of ribs.

14. The stent of claim 1, wherein the lumen is further configured to be placed in flow communication with a heart chamber and the stent is configured to flow blood between the heart chamber and the coronary vessel.

15. A method of implanting a stent within myocardial tissue to enhance perfusion therein, comprising:

providing a stent comprising a tubular member having first and second ends and a lumen, the first end configured to pierce myocardial tissue, the lumen being configured to be placed in flow communication with a coronary vessel, and means for retaining the tubular member within the myocardial tissue;

positioning the first end of the stent at a desired implantation site;

applying force to the second end of the stent to implant the stent within the myocardial tissue; and

engaging the means for retaining with the myocardial tissue to retain the stent in position.

16. The method as defined in claim 15 wherein positioning the first end of a stent at an implantation site comprises:

providing a delivery system;

loading the stent into the delivery system; and

inserting the delivery system percutaneously to position the first end of a stent at an implantation site.

17. The method as defined in claim 16 wherein the lumen has an inlet end and an outlet end, and wherein blood passes through the lumen from a cardiac chamber and into an epicardial artery.

18. The method as defined in claim 15 further comprising stimulating revascularization or tissue regeneration using a bioactive agent eluted from the stent.

19. The method as defined in claim 15 wherein the tubular member further comprises a flange projecting from the second end, the method further comprising when the flange abuts against a tissue surface, ceasing application of force to the second end of the stent.

20. The method as defined in claim 15 wherein the means for retaining comprises a plurality of tines or barbs, the method further comprising:

delivering the tubular member to an implantation site within a delivery sheath; and

retracting the delivery sheath to secure the stent within the myocardial tissue.

21. The method as defined in claim 15 wherein positioning the first end of a stent at an implantation site comprises:

providing a delivery system;

loading the stent into the delivery system;

and inserting the delivery system intraoperatively to position the first end of a stent at an implantation site.

22. The method of claim 15, wherein the lumen is further configured to be placed in flow communication with a heart chamber and the method further comprises flowing blood between the heart chamber and the coronary vessel via the stent.

23. A method of implanting a stent within myocardial tissue to enhance perfusion therein, comprising:

providing a stent comprising a tubular member having first and second ends and a lumen, the stent comprising a bioresorbable material impregnated with a bioactive agent and the lumen being configured to be placed in flow communication with a coronary vessel;

forming a channel in the myocardial tissue at a desired implantation site; and

inserting the stent within the channel to stimulate revascularization or tissue regeneration.

24. The method as defined in claim 23 further comprising eluting the bioactive agent from the bioresorbable material.

25. The method as defined in claim 24 further comprising securing the stent within the channel by applying sutures.

26. The method of claim 23, wherein the lumen is further configured to be placed in flow communication with a heart chamber and the method further comprises flowing blood between the heart chamber and the coronary vessel via the stent.